Obesity and diabetes are resulted from joint action of predisposing genetic and environmental factors. With the change of lifestyle and the continuous enrichment of social material supplies, obesity and diabetes have become public health concerns and major causes of morbidity and mortality worldwide. lifestyle factors, majorly include unhealthy eating habits and low physical activity level, contribute to the soaring burden of diabetes and obesity. Meanwhile, lifestyle factors are modifiable. Remission and reversion of diabetes and obesity related disorders (such as fatty liver disease, etc.) can be achieved through weight loss by changing lifestyles. Interestingly, there are some studies showing that in adults with diabetes or/and obesity, weight loss by intensive lifestyle intervention was associated with remission of type 2 diabetes, fatty liver disease, and metabolic syndrome. It has been reported that the remission of diabetes was strongly associated with the degree of weight loss.
The pathogenesis of obesity, diabetes and its complications are very complex, and the specific mechanism has not been fully understood. Emerging technology including genomics, metabolomics, proteomics, lipidomics, glycomics, and microbiome have improved our understanding of complex pathogenesis. Omics technology can not only explore dynamic changes in molecular graph of a single organ, but can also provide the interaction amongst various organs and tissues during the pathogenesis of disease. Exploring and integrating multi-omics information on the molecular mechanisms of obesity and diabetes would bring novel insight into the effects of lifestyle factors on individuals, thus may contribute to identifying potential interventions to prevent and even reverse the progression.
In this Research Topic, we welcome original research articles as well as review articles focusing on elucidating the molecular profiles of obesity and diabetes due to lifestyle factors. Potential topics include but are not limited to the following:
- Omics-driven findings on the etiology and pathogenesis of obesity and diabetes by lifestyle factors
- Multi-omics data integration to establish prediction models on occurrence of obesity and diabetes by lifestyle risk
- Omics-based investigation of the lifestyle factors (high fat diet, low protein diet, specific restricted diet, physical activity etc.) on obesity and diabetes
- Omics-based exploration of on complications of obesity and diabetes due to lifestyle intervention
- Omics-based exploration of interaction between lifestyle risk factors and medicine therapy on obesity and diabetes
Obesity and diabetes are resulted from joint action of predisposing genetic and environmental factors. With the change of lifestyle and the continuous enrichment of social material supplies, obesity and diabetes have become public health concerns and major causes of morbidity and mortality worldwide. lifestyle factors, majorly include unhealthy eating habits and low physical activity level, contribute to the soaring burden of diabetes and obesity. Meanwhile, lifestyle factors are modifiable. Remission and reversion of diabetes and obesity related disorders (such as fatty liver disease, etc.) can be achieved through weight loss by changing lifestyles. Interestingly, there are some studies showing that in adults with diabetes or/and obesity, weight loss by intensive lifestyle intervention was associated with remission of type 2 diabetes, fatty liver disease, and metabolic syndrome. It has been reported that the remission of diabetes was strongly associated with the degree of weight loss.
The pathogenesis of obesity, diabetes and its complications are very complex, and the specific mechanism has not been fully understood. Emerging technology including genomics, metabolomics, proteomics, lipidomics, glycomics, and microbiome have improved our understanding of complex pathogenesis. Omics technology can not only explore dynamic changes in molecular graph of a single organ, but can also provide the interaction amongst various organs and tissues during the pathogenesis of disease. Exploring and integrating multi-omics information on the molecular mechanisms of obesity and diabetes would bring novel insight into the effects of lifestyle factors on individuals, thus may contribute to identifying potential interventions to prevent and even reverse the progression.
In this Research Topic, we welcome original research articles as well as review articles focusing on elucidating the molecular profiles of obesity and diabetes due to lifestyle factors. Potential topics include but are not limited to the following:
- Omics-driven findings on the etiology and pathogenesis of obesity and diabetes by lifestyle factors
- Multi-omics data integration to establish prediction models on occurrence of obesity and diabetes by lifestyle risk
- Omics-based investigation of the lifestyle factors (high fat diet, low protein diet, specific restricted diet, physical activity etc.) on obesity and diabetes
- Omics-based exploration of on complications of obesity and diabetes due to lifestyle intervention
- Omics-based exploration of interaction between lifestyle risk factors and medicine therapy on obesity and diabetes