About this Research Topic
Vitamin C (L-ascorbate) is essential for human health and wellbeing. It is the most widely taken preventative, dietary supplement worldwide and although extreme deficiency (scurvy) is rare in modern society, some groups of people are more at risk. Low ascorbate levels have been associated with a variety of chronic diseases, including cancer, cardiovascular disease, atherosclerosis, pneumonia and sepsis. The role of ascorbate in cancer continues to be controversial, surrounded by hype and cynicism, and further robust scientific and clinical data is required to inform patients, physicians, the public and scientists.
In this Research Topic of Frontiers in Oncology, we would like to encourage submissions that cover the broad field of ascorbate in cancer, ranging from public health to biochemistry. We are interested in studies in cancer patients that address ascorbate status of patients, quality of life following ascorbate treatment, pharmacokinetics following high dose ascorbate administration, and controlled clinical trials, case-control studies and case reports. We also encourage submissions that describe studies in suitable animal models, with physiological and pharmacological levels of ascorbate, analyses of tumour pathology and response to therapy (chemotherapy and radiation), and investigations of the affected molecular pathways. We welcome submissions that address the molecular effects of ascorbate in cellular and cell-free systems, including those that aid our understanding of the anti- and pro-oxidant activities of ascorbate, and particularly ascorbate’s role as cofactor for vital enzymes. We encourage submissions of studies on ascorbate and dioxygenases that effect collagen production, methylation, miRNA processing and hypoxia-regulated pathways in cells.
We would like to receive research articles, as well as up to date reviews, and opinion commentaries.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.