About this Research Topic
As we approach the 10-year anniversary of the discovery of an important global regulator of secondary metabolism, LaeA, we would like to take this opportunity to review what has been learned about secondary metabolism in fungi in this Research Topic of Frontiers in Genetics. This Research Topic will put a spotlight on recent advances in the field and provide a framework for future directions aimed at elucidating and exploiting fungal secondary metabolism. As such, this Research Topic contains: synthetic biology approaches and heterologous systems for secondary metabolites, genomic mining for novel gene cluster discoveries, ecology of secondary metabolites, connection of secondary metabolism to development and stress responses, cross-talk of metabolites, next generation applications in cluster discoveries, virulence factors and genetic/epigenetic regulation of secondary metabolite gene clusters. The better understanding of the overall mechanisms leading to production of these natural products will facilitate the utilization and applications of their vast potential in medicine, food production, pharmacology and biotechnology. Therefore, the reviews and perspectives in this Research Topic cover a broad range of secondary metabolite research to give the readers a flexible concept and attract more public attention to the potential applications of the fungal natural products in the near future.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.