Research Topic

Injection Therapy for Chronic Musculoskeletal Pain

About this Research Topic

Chronic musculoskeletal pain is very common in the aging populations, with varying impact on functional, psychological, and social impairment. It is one of the most frequently encountered complaints in physicians’ offices, hospitals, chronic care facilities, and nursing homes. The management of chronic pain is a continuing public health problem and has major implications for patient care and health policy. While surgery is the last resort for certain conditions, the increasing prevalence has led to a need for effective non-surgical solutions such as physical therapy and pharmacological treatment. Injection therapy is an emerging treatment option when pain or functional limitations are significant despite oral medications and exercise. Examples of common injection agents include corticosteroids, which act on inflammatory mechanisms of pain and disease. Several techniques purport to act on non-inflammatory mechanisms, including hyaluronic acids, dextrose prolotherapy, autologous whole-blood and platelet rich plasma, with varying effectiveness. Other newer agents such as stems cells, nerve growth factors antibodies, and autologous protein solutions are emerging with less developed research.



This special issue of Injection Therapy for Chronic Musculoskeletal, a publication of the Frontiers in Pain Research, solicits papers that highlight the role of different injection therapies in chronic musculoskeletal pain. We invite authors to submit manuscripts involving original research including randomized clinical trials; observational research; systematic reviews; case series and pilot studies addressing different injection-based treatment in musculoskeletal pain management. Basic science and translational research studies that provide insight to underlying mechanisms of pain and its management are also encouraged. Areas of interest include different injection solutions, across different musculoskeletal regions in adults. Our goal for publication of this theme issue is to encourage authors to report their innovative research, and to enable clinicians to gain new insights to relieve pain in patients.


Keywords: Injection, Pain, dextrose, platelet rich plasma, blood, stem cells


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Chronic musculoskeletal pain is very common in the aging populations, with varying impact on functional, psychological, and social impairment. It is one of the most frequently encountered complaints in physicians’ offices, hospitals, chronic care facilities, and nursing homes. The management of chronic pain is a continuing public health problem and has major implications for patient care and health policy. While surgery is the last resort for certain conditions, the increasing prevalence has led to a need for effective non-surgical solutions such as physical therapy and pharmacological treatment. Injection therapy is an emerging treatment option when pain or functional limitations are significant despite oral medications and exercise. Examples of common injection agents include corticosteroids, which act on inflammatory mechanisms of pain and disease. Several techniques purport to act on non-inflammatory mechanisms, including hyaluronic acids, dextrose prolotherapy, autologous whole-blood and platelet rich plasma, with varying effectiveness. Other newer agents such as stems cells, nerve growth factors antibodies, and autologous protein solutions are emerging with less developed research.



This special issue of Injection Therapy for Chronic Musculoskeletal, a publication of the Frontiers in Pain Research, solicits papers that highlight the role of different injection therapies in chronic musculoskeletal pain. We invite authors to submit manuscripts involving original research including randomized clinical trials; observational research; systematic reviews; case series and pilot studies addressing different injection-based treatment in musculoskeletal pain management. Basic science and translational research studies that provide insight to underlying mechanisms of pain and its management are also encouraged. Areas of interest include different injection solutions, across different musculoskeletal regions in adults. Our goal for publication of this theme issue is to encourage authors to report their innovative research, and to enable clinicians to gain new insights to relieve pain in patients.


Keywords: Injection, Pain, dextrose, platelet rich plasma, blood, stem cells


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

04 December 2021 Abstract
02 February 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

04 December 2021 Abstract
02 February 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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