Research Topic

Road Map to next-generation regenerative medicine strategies of stem cells-fibrous scaffolds for heart and muscle-related ailments

About this Research Topic

Different stem and progenitor cells in the bone marrow and their application in cell therapy are constantly reviewed and the evidence for their therapeutic mechanisms is highly discussed in several reports. The combination with fibrous scaffolds has been gaining more intense research interest; especially for heart and muscle disorders. Although the development of the fibrous scaffold has a long history in managing various ailments related to heart muscle tissue, etc., its successful translational rate from bench to bedside has not been very significant. This renewed interest can be attributed to revisiting the technology that could reinforce the development of fibrous scaffolds for heart tissue management.

The fibrous scaffold is fabricated using ultrafast spintronics and an electron spun microfluidics electrospinning system integrated with stereolithographic 3D bioprinting could be ensuing generation to develop advanced materials for attaining the superior implants high throughput in tissue engineering applications. The fibrous scaffolds as carriers for the delivery of drugs are promising in the pharmaceutical industry in treating heart-related ailments. The significant advantage is the minimal side effects whereby different natural and synthetic composite materials can be used to fabric fibrous scaffolds.

These materials have had a greater success rate in preclinical studies using other stem cells in the past few decades because cells grow significantly in the fibrous environment. Studying the potential using imaging techniques has been gaining much attraction in tissue engineering research. Moreover, a combination of stem cells-fibrous scaffolds with growth factors or molecular agents, like DNA or RNA for the superior extracellular matrix, is a thought-provoking subject. In addition, the differentiation of stem cells and maintaining their phenotype in the 3D fibrous environment has been challenging. This Research Topic aims to summarize the most recent and state-of-the-art work in developing synergistic fibrous scaffolds and cell therapy and their uses in tissue engineering heart and muscle-related ailments. Topics we would like to encourage for submissions are highlighted, but are not limited to, in the following list:

● Development of Fibrous scaffold patches for myocardial damage etc.
● Role of stem cells loaded fibrous scaffolds for Myocardial damage
● Advanced fibrous tubular scaffolds for Heart valve in tissue engineering
● Stem cell’s synergistic role with fibrous scaffolds in combating Muscle weakness and differentiation
● Extracellular Matrix role in the development of nano-fibrous scaffold and stem cells treating
● Use of Stem cells and Polymer for Tissue regeneration
● 3D Printing of fibrous scaffolds Microfluidics and Fibrous scaffolds in Tissue engineering
● Electron spinning system integrated with stereolithographic 3D bioprinting for heart damage.
● Multilayer fibrous scaffolds for Cardiac tissue engineering.
● Cell-sheet engineering for Heart tissue repair.
● Fibrous scaffolds assembled from micropatterned electro-spun mats for cardiomyocyte culture.
● Matrix scaffolding for stem cell guidance toward Smooth and skeletal muscle tissue engineering

We would like to acknowledge Dr. Rajan Choudary's hard work and dedication to the development of this Research Topic in his role as a Coordinator, and thank him for his contribution as a valued member of the team.


Keywords: Heart, Muscle, Tissue engineering, Microfluidics, Stem cells, Electrospinning


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Different stem and progenitor cells in the bone marrow and their application in cell therapy are constantly reviewed and the evidence for their therapeutic mechanisms is highly discussed in several reports. The combination with fibrous scaffolds has been gaining more intense research interest; especially for heart and muscle disorders. Although the development of the fibrous scaffold has a long history in managing various ailments related to heart muscle tissue, etc., its successful translational rate from bench to bedside has not been very significant. This renewed interest can be attributed to revisiting the technology that could reinforce the development of fibrous scaffolds for heart tissue management.

The fibrous scaffold is fabricated using ultrafast spintronics and an electron spun microfluidics electrospinning system integrated with stereolithographic 3D bioprinting could be ensuing generation to develop advanced materials for attaining the superior implants high throughput in tissue engineering applications. The fibrous scaffolds as carriers for the delivery of drugs are promising in the pharmaceutical industry in treating heart-related ailments. The significant advantage is the minimal side effects whereby different natural and synthetic composite materials can be used to fabric fibrous scaffolds.

These materials have had a greater success rate in preclinical studies using other stem cells in the past few decades because cells grow significantly in the fibrous environment. Studying the potential using imaging techniques has been gaining much attraction in tissue engineering research. Moreover, a combination of stem cells-fibrous scaffolds with growth factors or molecular agents, like DNA or RNA for the superior extracellular matrix, is a thought-provoking subject. In addition, the differentiation of stem cells and maintaining their phenotype in the 3D fibrous environment has been challenging. This Research Topic aims to summarize the most recent and state-of-the-art work in developing synergistic fibrous scaffolds and cell therapy and their uses in tissue engineering heart and muscle-related ailments. Topics we would like to encourage for submissions are highlighted, but are not limited to, in the following list:

● Development of Fibrous scaffold patches for myocardial damage etc.
● Role of stem cells loaded fibrous scaffolds for Myocardial damage
● Advanced fibrous tubular scaffolds for Heart valve in tissue engineering
● Stem cell’s synergistic role with fibrous scaffolds in combating Muscle weakness and differentiation
● Extracellular Matrix role in the development of nano-fibrous scaffold and stem cells treating
● Use of Stem cells and Polymer for Tissue regeneration
● 3D Printing of fibrous scaffolds Microfluidics and Fibrous scaffolds in Tissue engineering
● Electron spinning system integrated with stereolithographic 3D bioprinting for heart damage.
● Multilayer fibrous scaffolds for Cardiac tissue engineering.
● Cell-sheet engineering for Heart tissue repair.
● Fibrous scaffolds assembled from micropatterned electro-spun mats for cardiomyocyte culture.
● Matrix scaffolding for stem cell guidance toward Smooth and skeletal muscle tissue engineering

We would like to acknowledge Dr. Rajan Choudary's hard work and dedication to the development of this Research Topic in his role as a Coordinator, and thank him for his contribution as a valued member of the team.


Keywords: Heart, Muscle, Tissue engineering, Microfluidics, Stem cells, Electrospinning


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

04 December 2021 Abstract
02 February 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

04 December 2021 Abstract
02 February 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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