About this Research Topic
The morphogenesis of fungi is tightly linked to their pathogenicity. To invade host and achieve immune escape, various polymorphic fungi such as Candida albicans, Aspergillus fumigatus and Ustilago maydis, can transit between different cellular forms. The ability of morphological transition is also referred as morphological plasticity which is regulated by epigenetics. To govern this process, epigenetic changes dictated by transcriptional factor networks are proven to be essential to orchestrate the transcriptome required for morphogenesis. Thus, discovering and establishing the roles of epigenetics in fungal morphogenesis will not only facilitate our understanding of morphological evolution of fungi, but also shed light on the development of novel therapeutic treatment.
Polymorphic fungi are important model organisms and many of them are pathogens threatening the safety of human and agriculture. This Research Topic aims to discover new epigenetic regulations, to reveal the functions of epigenetic regulations in fungal morphogenesis and pathogenesis, and to provide potential therapeutic targets.
We also aim to better understand the epigenetic mechanism of fungal morphogenesis and identify potential antifungal drug targets, including but not limited to human fungal pathogen and plant fungal pathogen.
1) identification of new epigenetic modifications (histone and DNA) during fungal morphogenesis;
2) establishing the roles of dynamic epigenetic modifications, chromatin remodeling and rewiring of the transcription factor network in fungal morphogenesis;
3) combining traditional antifungal drugs with new epigenetic targets to combat fungal infection;
Article types: original research, review, perspective, editorial.
Keywords: epigenetic regulation, fungal morphogenesis, fungal infection, polymorphic fungi
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