About this Research Topic
Mitochondria are important organelles found in the cells of the human body. Organs or tissues with the highest mitochondrial volume density include kidney (29.3%), heart (21.0%), liver (14.4%), brain (7.0%), skeletal muscle (5.0%). The dominant role of mitochondria is to produce energy in the form of molecular ATP. Inefficient mitochondrial function results in lower working efficiency on important organs, especially heart, liver, and kidney. Tiredness is a common symptom in diabetic and obese people, which links to dysfunctional mitochondria. Therefore, obesity and diabetes have much to do with mitochondrial defects.
Tracking changes in the abundance and function of mitochondrial key-proteins might be an efficient and fast way to reveal the mechanisms underneath mitochondrial defects in obese and diabetic, especially in mitochondrion-rich organs, such as heart, liver, and kidney. Oxidative phosphorylation, commonly carried on by Seahorse Assay, is one of the most important and useful techniques to evaluate mitochondrial efficiency. Also, crosstalk between mitochondrion and other organelles such as endoplasmic reticulum and peroxisome should be taken into consideration.
This Research Topic of Frontiers in Endocrinology would accept articles involved in:
1. Obesity-Inducing Insulin Resistance animal model / NAFLD
2. Abundance changes of mitochondrial proteins by Mass Spec Analyses
3. Seahorse Assays on obese/diabetes human or animal biopsies
4. Mitochondrial protein gene knockout in mice
5. Mitochondrial protein gene CRISPR knockout in regular cell lines or iPSC
Tracking changes in the abundance and function of mitochondrial key-proteins might be an efficient and fast way to reveal the mechanisms underneath mitochondrial defects in obese and diabetic, especially in mitochondrion-rich organs, such as heart, liver, and kidney. Oxidative phosphorylation, commonly carried on by Seahorse Assay, is one of the most important and useful techniques to evaluate mitochondrial efficiency. Also, crosstalk between mitochondrion and other organelles such as endoplasmic reticulum and peroxisome should be taken into consideration.
This Research Topic of Frontiers in Endocrinology would accept articles involved in:
1. Obesity-Inducing Insulin Resistance animal model / NAFLD
2. Abundance changes of mitochondrial proteins by Mass Spec Analyses
3. Seahorse Assays on obese/diabetes human or animal biopsies
4. Mitochondrial protein gene knockout in mice
5. Mitochondrial protein gene CRISPR knockout in regular cell lines or iPSC
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
