About this Research Topic
This research topic focuses on the bioenergetic deficits and activation of inflammatory responses, their redox (oxidative stress) regulation, and their role in synaptic plasticity and cognition in healthy brain aging and neurodegenerative diseases. Dynamic interactions among these systems will be reviewed in terms of their causative or in-tandem occurrence and how does the systemic environment, e.g., insulin resistance, diabetes, and inflammation, impact on brain function. This call for papers also aims to create a unique forum for in-depth discussions on cellular mechanisms and their forward translation into interventions to prevent, delay, or treat the memory loss and cognitive slowing associated with brain aging and neurodegeneration, as well as the reverse translation from the progression of clinical studies (e.g., non-invasive neuroimaging techniques) to the basic discovery research.
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