About this Research Topic
Present the problem that you would like to tackle in this Research topic and what can be done to achieve it including recent advances.
This Research Topic aims to address how much of this basic knowledge on innate immune cells is useful to predict and solve human ailments with underlying immunopathologies. Evidence of the interaction between the innate and adaptive immune cells can be borne out of in vitro, in vivo and ex vivo experiments using preclinical models as well as human primary immune cells, be it in natural as well as in vaccine related immune responses against infectious diseases or cancer. Observations derived from human data in ‘steady state’ as well as from patients undergoing therapy and from humanized immune system mice can greatly improve our knowledge. Recent advancements in investigations focused on human immunopathologies as well as in instances where the immune system impedes delivery and action of biological therapeutics, provide opportunities to validate and extend the relevance of the role of innate immune cells in mechanistically controlling adaptive immune responses. Further, it is also important to understand the role of innate immune cells in the development of autoimmune and autoinflammatory responses as well as in cases of immunogenicity against protein, gene and cell therapeutics.
This Research Topic welcomes the submission of manuscripts focusing on, but not limited to, the following sub-topics:
• Human innate immune cells in different tissues: phenotype, development and function in physiopathology
• Activation and regulation of T cells and B cells by innate immune cells (MNPs, PMNs, NK cells and ILCs) resulting in human immunopathologies
• Tolerance inducing pathways in human antigen presenting cells and modulation of adaptive immune responses
• Murine models with Humanized Immune system – tools to study innate adaptive immune cross-talks in humans
• Immunogenicity of protein, gene and cell therapeutics: role of innate immune cells in human and non-human in vivo and in vitro models
Keywords: mononuclear phagocytes, polymorphonuclear cells, innate immunity, adaptive immunity, human immune pathology, immunogenicity
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.