About this Research Topic
Endocrine disrupting chemicals (EDCs) or compound structures altering the endocrine system, as well as the in-depth understanding of pathogenetic mechanisms of endocrine disorders, cannot be modelled in simple or cell-based systems. Consequently, in vivo studies are used to effectively model human experience; such experiments allow for potentially translational application in clinical contexts.
EDC research relies on whole-organism-based tools to identify influence on a physiological, behavioral, and molecular level; in vitro experiments cannot typically provide such results. Likewise, adrenal Endocrinologists often use rodent models with the benefit of short generation times and possibility to replicate phenotypes and genotypes. Zebrafish, dogs, and ferrets are also used in adrenal experiments.
The need for translational results of in vivo experiments means that choosing the correct model organisms is of core importance. Furthermore, application of human-relevant doses, testing at appropriate life-stages, and the use of appropriately susceptible species provide most valuable results for application in human health. These tests aim for comprehensive assessment of complex disorders lacking clear pathology, as well as the identification and/or prediction of endocrine-related disorders.
This Research Topic focuses on model organisms in adrenal endocrinology, welcoming contributions demonstrating translational outcomes or barriers to these in model organism use. The collection also seeks to identify the most relevant model organisms for use in adrenal endocrinology, thus allowing future research to apply relevant models to their in vivo experiments.
Articles will be accepted pertaining to, but not limited to, the following:
- Effective model organisms for understanding adrenal function;
- Effective model organisms for understanding adrenal diseases;
- Appropriate modelling within in vivo experiments to define novel therapeutic possibilities.
EDC research relies on whole-organism-based tools to identify influence on a physiological, behavioral, and molecular level; in vitro experiments cannot typically provide such results. Likewise, adrenal Endocrinologists often use rodent models with the benefit of short generation times and possibility to replicate phenotypes and genotypes. Zebrafish, dogs, and ferrets are also used in adrenal experiments.
The need for translational results of in vivo experiments means that choosing the correct model organisms is of core importance. Furthermore, application of human-relevant doses, testing at appropriate life-stages, and the use of appropriately susceptible species provide most valuable results for application in human health. These tests aim for comprehensive assessment of complex disorders lacking clear pathology, as well as the identification and/or prediction of endocrine-related disorders.
This Research Topic focuses on model organisms in adrenal endocrinology, welcoming contributions demonstrating translational outcomes or barriers to these in model organism use. The collection also seeks to identify the most relevant model organisms for use in adrenal endocrinology, thus allowing future research to apply relevant models to their in vivo experiments.
Articles will be accepted pertaining to, but not limited to, the following:
- Effective model organisms for understanding adrenal function;
- Effective model organisms for understanding adrenal diseases;
- Appropriate modelling within in vivo experiments to define novel therapeutic possibilities.
Keywords: rodent, model, model organism, zebra fish
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
