About this Research Topic
There is no restorative treatment for deafness but functional replacement by means of prosthesis. Therefore, prevention and treatment of hearing loss is an unmet medical need. To develop innovative medical strategies against hearing loss, it is critical to understand the causes of ARHL and the essential pathways responsible for the manifestation of this complex disease.
In this research topic, experts will discuss the stages and molecular elements of the damage and repair processes involved in ARHL, from cellular processes involved in ageing as senescence and autophagy, to molecules essential for hearing as IGF-1 and neurotrophins. Neuroinflammation takes a central stage as an essential element in the progression of injury and cell loss, and a target for cell protection strategies. Neurogenesis is also essential to understand the adult cochlea self-repair potential. Finally, the mechanisms of action and the potential of novel therapies for hair cell repair and protection will be discussed along with drug delivery strategies.
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