About this Research Topic
Viruses are intracellular pathogens that rely on hijacking host resources to complete their life cycle. Specifically, upon infection of hosts, efficient viral replication and virion biogenesis are processes that need an extremely high turnover of cellular molecules such as metabolites that are intermediates or products of biochemical reactions. Therefore, it is not surprising that many viruses have evolved numerous strategies to shape metabolic rewiring in host cells solely facilitate optimal virus production. Meanwhile, such metabolic alterations also involve in mounting the host immune responses that impact the outcome of infection. Improved understanding of cellular metabolic rewiring upon viral infection could provide the key insights into a novel aspect of virus-host interaction, with a view toward therapeutic intervention.
This Research Topic aims to highlight recent discoveries in understanding of how viruses and virus-encoded proteins modulate cellular metabolic pathways for their fitness and how the hosts utilize metabolic adaptions to overcome viral infection. Contributions should focus on the mechanistic studies identifying viral component(s) for metabolic rewiring as well as consequences of virus-induced metabolic reprogramming, and the manipulation of metabolic events in vivo to change the progression of virus infection. Studies on improved technologies for detailed metabolic measurements in vitro or in vivo during virus infection are also invited.
The scope of this Research Topic is to provide readers a comprehensive understanding of virus-host interaction in terms of metabolism, highlighting the novel antiviral approaches through targeted inhibition of specific cellular metabolic pathways. We welcome the submission of article types including Review, Original Research, and Perspective.
This Research Topic aims to highlight recent discoveries in understanding of how viruses and virus-encoded proteins modulate cellular metabolic pathways for their fitness and how the hosts utilize metabolic adaptions to overcome viral infection. Contributions should focus on the mechanistic studies identifying viral component(s) for metabolic rewiring as well as consequences of virus-induced metabolic reprogramming, and the manipulation of metabolic events in vivo to change the progression of virus infection. Studies on improved technologies for detailed metabolic measurements in vitro or in vivo during virus infection are also invited.
The scope of this Research Topic is to provide readers a comprehensive understanding of virus-host interaction in terms of metabolism, highlighting the novel antiviral approaches through targeted inhibition of specific cellular metabolic pathways. We welcome the submission of article types including Review, Original Research, and Perspective.
Keywords: viruses, viral replication, cellular metabolism, metabolic pathways, immune response, antiviral therapy
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
