Intestinal microbes (e.g., Salmonella and Yersinia pseudotuberculosis) and enteroviruses (e.g. Enterovirus D68 and Coxsackievirus) can cause gastrointestinal infections in humans, which often have a high incidence of infection, rapid spread, and high incidence of drug resistance. Due to the interactions between the intestinal microbes and host metabolism, gastrointestinal infections may influence the epigenetic regulation and the status of the epigenome of the host. In particular, gastrointestinal infections may be involved in the occurrence of inflammatory bowel disease, autoimmune arthritis, asthma, and other diseases.
Recent high-throughput multi-omics techniques such as (meta) genomics, transcriptomics, proteomics, and metabolomics have produced in-depth high-resolution data. Carrying out multi-omics analyses and applications based on massive data is conducive to systematically exploring the interactions between host-pathogens, immune molecules, and their operational changes. The functions and properties of immune molecules and immune cell subsets help to reveal their role in immune responses and diseases; help to identify key molecular players involved in host-pathogen interactions; and identify potential novel drug targets for the treatment of a variety of diseases.
The aim of this Research Topic is therefore to focus on the use of multi-omics to study the mechanisms of intestinal pathogens and host immunity. We welcome research combining omics-data with intestinal host-pathogen interactions and linking their functions to help us better understand their specific roles in the immune mechanisms of intestinal infectious diseases, and host-pathogen interactions with specific molecular mechanisms in human health and disease.
We welcome original research, reviews, mini-reviews, perspectives, and concept-driven methodologies on but not limited to the following topics:
1. Integrating single-cell sequencing, metagenomic sequencing, spatial transcriptome, cell imaging, and other methods to reveal the immune characteristics of the intestinal microenvironment during intestinal infections.
2. Integrating whole genome sequencing multi-omics analysis to identify the occurrence and participation of epigenetic modifications, in interactions between foodborne enteric pathogens and the host immune system.
3. Identifying epigenetic factors such as post-translational modifications and their mediated immunological signaling associated with inflammation induced by intestinal pathogens.
4. The potential action mechanisms, of epigenetic modifications in the pathogenic mechanisms of evading host innate responses during diseases caused by intestinal pathogens.
5. Identifying key molecular players involved in host-pathogen interactions, host defense/restriction responses to eliminate infections, and reveal potential targets for the treatment of intestinal infectious disease.
Intestinal microbes (e.g., Salmonella and Yersinia pseudotuberculosis) and enteroviruses (e.g. Enterovirus D68 and Coxsackievirus) can cause gastrointestinal infections in humans, which often have a high incidence of infection, rapid spread, and high incidence of drug resistance. Due to the interactions between the intestinal microbes and host metabolism, gastrointestinal infections may influence the epigenetic regulation and the status of the epigenome of the host. In particular, gastrointestinal infections may be involved in the occurrence of inflammatory bowel disease, autoimmune arthritis, asthma, and other diseases.
Recent high-throughput multi-omics techniques such as (meta) genomics, transcriptomics, proteomics, and metabolomics have produced in-depth high-resolution data. Carrying out multi-omics analyses and applications based on massive data is conducive to systematically exploring the interactions between host-pathogens, immune molecules, and their operational changes. The functions and properties of immune molecules and immune cell subsets help to reveal their role in immune responses and diseases; help to identify key molecular players involved in host-pathogen interactions; and identify potential novel drug targets for the treatment of a variety of diseases.
The aim of this Research Topic is therefore to focus on the use of multi-omics to study the mechanisms of intestinal pathogens and host immunity. We welcome research combining omics-data with intestinal host-pathogen interactions and linking their functions to help us better understand their specific roles in the immune mechanisms of intestinal infectious diseases, and host-pathogen interactions with specific molecular mechanisms in human health and disease.
We welcome original research, reviews, mini-reviews, perspectives, and concept-driven methodologies on but not limited to the following topics:
1. Integrating single-cell sequencing, metagenomic sequencing, spatial transcriptome, cell imaging, and other methods to reveal the immune characteristics of the intestinal microenvironment during intestinal infections.
2. Integrating whole genome sequencing multi-omics analysis to identify the occurrence and participation of epigenetic modifications, in interactions between foodborne enteric pathogens and the host immune system.
3. Identifying epigenetic factors such as post-translational modifications and their mediated immunological signaling associated with inflammation induced by intestinal pathogens.
4. The potential action mechanisms, of epigenetic modifications in the pathogenic mechanisms of evading host innate responses during diseases caused by intestinal pathogens.
5. Identifying key molecular players involved in host-pathogen interactions, host defense/restriction responses to eliminate infections, and reveal potential targets for the treatment of intestinal infectious disease.
