Research Topic

Role of Stem Cells in Skeletal Muscle Development, Regeneration, Repair, Aging and Disease

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Adult stem cells are responsible for tissue regeneration and repair throughout life. Their quiescence or activation is tightly regulated by common signaling pathways that often recapitulate those happening during embryonic development, and thus it is important to understand their regulation not only in ...

Adult stem cells are responsible for tissue regeneration and repair throughout life. Their quiescence or activation is tightly regulated by common signaling pathways that often recapitulate those happening during embryonic development, and thus it is important to understand their regulation not only in postnatal life, but also during fetal development. In this regard, skeletal muscle is an interesting tissue since it accounts for a large percentage of body mass (about 40%), it is highly amenable to intervention through exercise and it is also key in metabolic and physiological changes underlying frailty susceptibility in the elderly. While muscle-resident satellite cells are responsible for all myogenic activity in physiological conditions and become senescent in old age, other progenitor cells such as mesoangioblasts do seem to contribute to muscle regeneration and repair after tissue damage. Similarly, fibro-adipogenic precursor cells seem to be key in the aberrant response that fills up the space left from atrophied muscle mass and which ends up with a dysfunctional muscle having vast areas of fatty infiltration and fibrosis. The complex interplay between these stem/progenitor cell types and their niches in normal and pathological conditions throughout life are the subjects of intense investigation. This Research Topic aims to highlight recent developments on the role of stem cells in skeletal muscle function, both in prenatal and postnatal life, and their regulation by transcriptional, post-transcriptional and epigenetic mechanisms. Additionally, we welcome articles on interventions associated with exercise, pathological changes in neuromuscular diseases, and stem cell aging. Contributors are encouraged to submit reviews, mini-reviews, commentaries, perspectives, research articles and theoretical papers.


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