Neurodevelopmental disorders (NDDs) are a group of heterogenous disorders with early age-onset that are primarily associated with neurodevelopmental dysfunctions, which mainly include autism spectrum disorder (ASD), developmental delay (DD), intellectual disability (ID), attention-deficit/hyperactivity disorder (ADHD) and other motor or communication/language disorders. NDDs have high levels of heterogeneity at the phenotypic and genetic levels, as well as their underlying etiologies which are largely yet to be revealed. Genetic factors are believed to play an important role in NDDs. With the advent of next-generation sequencing technologies such as targeted sequencing, exome or genome sequencing and the more recent third-generation sequencing technologies (i.e. Long-read sequencing), hundreds of high-confidence risk genes of human disease have been identified with detailed genotype-phenotype correlations, and the underlying mechanisms were discovered. However, more causative genes related to NDDs, as well as the mechanisms, are awaited to be discovered.
The goal of this Research Topic is to identify the progress of the genetic and functional studies related to NDDs, especially the omics-based findings and their basic and clinical applications in NDDs. We welcome submissions on novel gene discoveries and genetic mechanisms, treatment studies using but not limited to animal or cellular models, new diagnostic approaches, integrated databases, and genetic resources, and the dissecting of the phenotypic clinical and genetic heterogenicity in NDDs. Clinical observation/management/treatment study for one particular genetic NDDs is covered also. We welcome submissions of original research papers, brief research reports, reviews, and methods, etc. that cover the topics above.
We welcome submissions that cover recent, promising, and novel research trends in the genetics of NDDs. Areas to be covered in this Research Topic may include, but are not limited to:
1. The description and sequencing of cohorts with NDDs
2. The databases and genetic resources for NDDs
3. The clinical heterogeneity of cohort with NDDs by genetic dissection
4. The identification of new causative genes or loci in NDDs
5. The phenomics dissection study of one kind of gene/pathway-related NDDs
6. The pathogenic mechanisms study of genes or loci in NDDs using animal or patient-induced pluripotent stem cells (iPSCs)
7. The in vivo/in vitro treatment study for one particular genetic NDDs using animal or patient iPSCs
8. The neurodevelopmental trajectory or clinical treatment/management for one particular genetic NDDs.
Neurodevelopmental disorders (NDDs) are a group of heterogenous disorders with early age-onset that are primarily associated with neurodevelopmental dysfunctions, which mainly include autism spectrum disorder (ASD), developmental delay (DD), intellectual disability (ID), attention-deficit/hyperactivity disorder (ADHD) and other motor or communication/language disorders. NDDs have high levels of heterogeneity at the phenotypic and genetic levels, as well as their underlying etiologies which are largely yet to be revealed. Genetic factors are believed to play an important role in NDDs. With the advent of next-generation sequencing technologies such as targeted sequencing, exome or genome sequencing and the more recent third-generation sequencing technologies (i.e. Long-read sequencing), hundreds of high-confidence risk genes of human disease have been identified with detailed genotype-phenotype correlations, and the underlying mechanisms were discovered. However, more causative genes related to NDDs, as well as the mechanisms, are awaited to be discovered.
The goal of this Research Topic is to identify the progress of the genetic and functional studies related to NDDs, especially the omics-based findings and their basic and clinical applications in NDDs. We welcome submissions on novel gene discoveries and genetic mechanisms, treatment studies using but not limited to animal or cellular models, new diagnostic approaches, integrated databases, and genetic resources, and the dissecting of the phenotypic clinical and genetic heterogenicity in NDDs. Clinical observation/management/treatment study for one particular genetic NDDs is covered also. We welcome submissions of original research papers, brief research reports, reviews, and methods, etc. that cover the topics above.
We welcome submissions that cover recent, promising, and novel research trends in the genetics of NDDs. Areas to be covered in this Research Topic may include, but are not limited to:
1. The description and sequencing of cohorts with NDDs
2. The databases and genetic resources for NDDs
3. The clinical heterogeneity of cohort with NDDs by genetic dissection
4. The identification of new causative genes or loci in NDDs
5. The phenomics dissection study of one kind of gene/pathway-related NDDs
6. The pathogenic mechanisms study of genes or loci in NDDs using animal or patient-induced pluripotent stem cells (iPSCs)
7. The in vivo/in vitro treatment study for one particular genetic NDDs using animal or patient iPSCs
8. The neurodevelopmental trajectory or clinical treatment/management for one particular genetic NDDs.