The Wnt/ß-catenin signaling is a highly conserved pathway that orchestrates several biological functions, such as cell proliferation and differentiation, migration, apoptosis, and stem cell renewal. Unsurprisingly, aberrant regulation of the Wnt/ß-catenin pathway has been frequently described as a crucial player in both solid tumors and hematological malignancies.
Due to its prominent role in tumorigenesis and cancer progression, an increasing number of studies have been focused on the therapeutic potential of targeting the Wnt/ß-catenin signaling cascade. However, a better understanding of the factors involved in the Wnt/ß-catenin driven tumorigenesis and their response to the present cancer treatments is necessary to develop innovative diagnostic tools and targeted therapies.
In this Research Topic, we welcome studies that focus on, but are not limited to:
Insights on Wnt/ß-catenin signaling dysregulation associated with cancer
- Identification of members of the Wnt/ß-catenin signaling cascade involved in tumorigenesis and tumor progression, and their potential as therapeutic targets
- The interplay between current cancer treatment and the Wnt/ß-catenin pathway
- Clinical translations of Wnt/ß-catenin signaling-dependent targeted therapies
Please note: Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in any of the sections of Frontiers in Oncology.
The Wnt/ß-catenin signaling is a highly conserved pathway that orchestrates several biological functions, such as cell proliferation and differentiation, migration, apoptosis, and stem cell renewal. Unsurprisingly, aberrant regulation of the Wnt/ß-catenin pathway has been frequently described as a crucial player in both solid tumors and hematological malignancies.
Due to its prominent role in tumorigenesis and cancer progression, an increasing number of studies have been focused on the therapeutic potential of targeting the Wnt/ß-catenin signaling cascade. However, a better understanding of the factors involved in the Wnt/ß-catenin driven tumorigenesis and their response to the present cancer treatments is necessary to develop innovative diagnostic tools and targeted therapies.
In this Research Topic, we welcome studies that focus on, but are not limited to:
Insights on Wnt/ß-catenin signaling dysregulation associated with cancer
- Identification of members of the Wnt/ß-catenin signaling cascade involved in tumorigenesis and tumor progression, and their potential as therapeutic targets
- The interplay between current cancer treatment and the Wnt/ß-catenin pathway
- Clinical translations of Wnt/ß-catenin signaling-dependent targeted therapies
Please note: Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in any of the sections of Frontiers in Oncology.
