Myeloid-derived suppressor cells (MDSCs) are important immune suppressive cells mainly in malignant diseases and some inflammatory diseases. The role of MDSCs in chronic inflammatory diseases was controversial. They relieve the inflammatory activities of chronic hepatitis B but promote the development of chronic hepatitis B-related cancer, hepatocellular carcinoma. Moreover, MDSCs are related to tumor recurrence in chronic hepatitis patients. These studies indicate the distinct role of MDSC in chronic hepatitis. Besides, novel subtypes of MDSCs have been found in neonates and in vitro-generated MDSCs, which could relieve multiple inflammatory diseases in mice models. Unlike MDSCs in cancer which only show the immune suppressive function, these MDSCs display not only immune suppressive function but also, surprisingly, anti-infection capability. These subtypes of MDSCs might be a potential remedy for inflammatory diseases. Thus, it is critical to investigate the role of MDSCs in chronic inflammatory diseases.
We welcome submissions of Original Research and Review on the sub-topics below:
• The role of myeloid-derived suppressor cells (MDSCs) in the development of inflammatory diseases and cancers
• The role of MDSCs in inflammatory diseases related complications.
• The potential therapeutic effects and safety profiles of MDSCs on inflammatory diseases and cancers
• The interaction of MDSCs with other immune cells in inflammatory diseases and cancers
• The regulatory mechanism of MDSCs in inflammatory diseases, their complications, and cancers
• The methods of in vitro generation of MDSCs
Note: Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic
Myeloid-derived suppressor cells (MDSCs) are important immune suppressive cells mainly in malignant diseases and some inflammatory diseases. The role of MDSCs in chronic inflammatory diseases was controversial. They relieve the inflammatory activities of chronic hepatitis B but promote the development of chronic hepatitis B-related cancer, hepatocellular carcinoma. Moreover, MDSCs are related to tumor recurrence in chronic hepatitis patients. These studies indicate the distinct role of MDSC in chronic hepatitis. Besides, novel subtypes of MDSCs have been found in neonates and in vitro-generated MDSCs, which could relieve multiple inflammatory diseases in mice models. Unlike MDSCs in cancer which only show the immune suppressive function, these MDSCs display not only immune suppressive function but also, surprisingly, anti-infection capability. These subtypes of MDSCs might be a potential remedy for inflammatory diseases. Thus, it is critical to investigate the role of MDSCs in chronic inflammatory diseases.
We welcome submissions of Original Research and Review on the sub-topics below:
• The role of myeloid-derived suppressor cells (MDSCs) in the development of inflammatory diseases and cancers
• The role of MDSCs in inflammatory diseases related complications.
• The potential therapeutic effects and safety profiles of MDSCs on inflammatory diseases and cancers
• The interaction of MDSCs with other immune cells in inflammatory diseases and cancers
• The regulatory mechanism of MDSCs in inflammatory diseases, their complications, and cancers
• The methods of in vitro generation of MDSCs
Note: Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic