Research Topic

How to Improve Cord Blood Transplantation: By Enhancing Cell Counts or Engraftment?

  • Submission closed.

About this Research Topic

Cord blood is a widely used source of hematopoietic stem cell (HSC) transplants. Despite multiple limitations the number of unrelated cord blood transplants (CBT) are steadily increasing. Low HSC content initially limited CBTs to pediatric patients. Later double CBTs became a source of HSC transplantation for ...

Cord blood is a widely used source of hematopoietic stem cell (HSC) transplants. Despite multiple limitations the number of unrelated cord blood transplants (CBT) are steadily increasing. Low HSC content initially limited CBTs to pediatric patients. Later double CBTs became a source of HSC transplantation for adults who are not well represented within donor registries and thus lack an HLA identical donor. As a result CBT is one of the tools to overcome HLA barriers, very similar to haploidentical transplants. Although previously regarded as an advantage, mismatched transplants and using one log less HSCs cause infectious complications or engraftment delays. Scientific improvements towards ex vivo expansion and engraftment enhancing methods are now becoming widely recognized. These promising tools can overcome the major challenges arising from transplantation of insufficient number of HSCs. Contributions to this research topic will describe the current "cord blood transplantation: state of art" and recent tools that will increase the utility of CBUs among many patients seeking cure for hematological diseases. Furthermore cord blood has also a potential for induction of pluripotent cells which may have regenerative potential. Lack of complete regeneration of certain cells such as neurons, cardiac and hepatic tissue following injury is still an unmet need leading to thousands of deaths every year. Various attempts to repair adult tissues with cord blood cells have been successful in pre-clinical models. Pharma has demonstrated a growing interest in developing novel techniques to implement cord blood cells into clinics for regenerative purposes. CBBs can be a good source for obtaining NK or progenitors to be stored and further used “off the shelf” on demand. The immunologically naïve nature of cord blood cells in addition to their long telomers constitute this “off the shelf” potency. Furthermore, cord blood is easily accessible and capacity is not a limitation compared to stem cell sources of adult origin. Finally, cord blood harbour stem cells closest to fetal life and lack ethical concerns. Recent methodological advances have enabled harvest of induced pluripotent stem (iPS) cells from CB and is now accepted as a new potential application.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Recent Articles

Loading..

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..

Comments

Loading..

Add a comment

Add comment
Back to top