Oxidative stress refers to a imbalance between oxidant and antioxidant species. Although low levels of oxidants are needed for signaling purpose, an increase in oxidative stress regulation can be hazardous to the organism. Oxidative stress is considered as a cause of various endocrine dysfunctions including impaired thyroid functions, as well as cardiac, renal and vascular complications.
Keeping the intracellular redox state is required for the normal function of ovaries and hypothalamo-pituitary-ovarian axis. Progressive female age, obesity, and unexplained infertility are associated with a dis-balance in the oxidant environment. Recent advances are evident that oxidative stress may affect the bioactivity of reproductive hormones causing inadequate oocyte maturation, impaired fertilization, decreased cleavage, and pregnancy loss. Therefore, increased oxidative stress may be potentially linked to increased risk for sub-fertility, deteriorated embryo quality, decreased endometrial receptivity, implantation failure and increased miscarriage rate.
The aim of the current Research Topic is to cover and review the promising, recent, and novel research trends in the effect of oxidative stress in thyroid disorders and implications of its deficiency on reproduction.
Areas to be covered in this Research Topic will include:
- Genetic variations like SIRT1 causing oxidative stress
- Interaction between oxidative stress, Vitamin D and reproductive hormones
- Effects of oxidative stress management on fertility outcomes
- Advanced proteomic techniques for analysis of oxidative stress in reproductive disorders
Oxidative stress refers to a imbalance between oxidant and antioxidant species. Although low levels of oxidants are needed for signaling purpose, an increase in oxidative stress regulation can be hazardous to the organism. Oxidative stress is considered as a cause of various endocrine dysfunctions including impaired thyroid functions, as well as cardiac, renal and vascular complications.
Keeping the intracellular redox state is required for the normal function of ovaries and hypothalamo-pituitary-ovarian axis. Progressive female age, obesity, and unexplained infertility are associated with a dis-balance in the oxidant environment. Recent advances are evident that oxidative stress may affect the bioactivity of reproductive hormones causing inadequate oocyte maturation, impaired fertilization, decreased cleavage, and pregnancy loss. Therefore, increased oxidative stress may be potentially linked to increased risk for sub-fertility, deteriorated embryo quality, decreased endometrial receptivity, implantation failure and increased miscarriage rate.
The aim of the current Research Topic is to cover and review the promising, recent, and novel research trends in the effect of oxidative stress in thyroid disorders and implications of its deficiency on reproduction.
Areas to be covered in this Research Topic will include:
- Genetic variations like SIRT1 causing oxidative stress
- Interaction between oxidative stress, Vitamin D and reproductive hormones
- Effects of oxidative stress management on fertility outcomes
- Advanced proteomic techniques for analysis of oxidative stress in reproductive disorders
