Worldwide mortality is substantially impacted by non-communicable diseases (NCD) which frequency has been showing an increasing trend in recent years. These type of disease results from the combined effects of the human genome and exposome which represents all exposures of an individual that begin before birth and include insults from environmental and occupational sources across the entire life span. Environmental exposures, such as outdoor and indoor air pollution, water pollution, exposure to endocrine-disrupting chemicals, persistent organic pollutants, toxic metals, etc. have been shown to significantly contribute to the rise of the burden of many NCD.Research so far has not focused on human reproductive and NCD concerns following exposure to environmental toxicants. And with toxic compounds also being toxic to both the mother and the developing child, it could promote the development of NCD in the fetus. There have been few collections that examine our current understanding of the role for environmental toxicants and reproductive/developmental-associated NCDs. By bringing together investigators that are at the forefront of their field, this collection will provide a consolidated body of work that will add to our mechanistic understanding of environmental toxicant exposure on reproductive and developmental NCDs. Submissions for this collection will examine the current state of our understanding and advance to cellular/molecular/genetic studies to deepen our knowledge of reproductive/developmental NCDs associated with environmental toxicant exposures.Submitted papers are expected to make a significant contribution to understanding the association between environmental exposures and NCD. Possible topics include, but are not limited to:• Early environmental exposures and the risk of developing NCD in later life stages (obesity, asthma, autoimmune diseases, diabetes, endocrine and reproductive disorders, cardiovascular disease and neurodevelopmental /neurodegenerative conditions)• Identify biological mechanisms of environmental exposures that are influencing NCD risk• Establishing the model of environmental exposures across the life course (exposome investigations)• Explore the role of gene-environment interactionsOriginal research articles, review articles, as well as short communications are invited.
Worldwide mortality is substantially impacted by non-communicable diseases (NCD) which frequency has been showing an increasing trend in recent years. These type of disease results from the combined effects of the human genome and exposome which represents all exposures of an individual that begin before birth and include insults from environmental and occupational sources across the entire life span. Environmental exposures, such as outdoor and indoor air pollution, water pollution, exposure to endocrine-disrupting chemicals, persistent organic pollutants, toxic metals, etc. have been shown to significantly contribute to the rise of the burden of many NCD.Research so far has not focused on human reproductive and NCD concerns following exposure to environmental toxicants. And with toxic compounds also being toxic to both the mother and the developing child, it could promote the development of NCD in the fetus. There have been few collections that examine our current understanding of the role for environmental toxicants and reproductive/developmental-associated NCDs. By bringing together investigators that are at the forefront of their field, this collection will provide a consolidated body of work that will add to our mechanistic understanding of environmental toxicant exposure on reproductive and developmental NCDs. Submissions for this collection will examine the current state of our understanding and advance to cellular/molecular/genetic studies to deepen our knowledge of reproductive/developmental NCDs associated with environmental toxicant exposures.Submitted papers are expected to make a significant contribution to understanding the association between environmental exposures and NCD. Possible topics include, but are not limited to:• Early environmental exposures and the risk of developing NCD in later life stages (obesity, asthma, autoimmune diseases, diabetes, endocrine and reproductive disorders, cardiovascular disease and neurodevelopmental /neurodegenerative conditions)• Identify biological mechanisms of environmental exposures that are influencing NCD risk• Establishing the model of environmental exposures across the life course (exposome investigations)• Explore the role of gene-environment interactionsOriginal research articles, review articles, as well as short communications are invited.