About this Research Topic
In fact, lipids are crucial in the pathophysiology of cancer development. Several types of cancers share common alterations in cell lipid metabolism. These dysregulated changes can affect several physiological characteristics of cells such as membrane synthesis, energy homeostasis, post-translational protein modifications, and cell signaling, thus sustaining cell growth, proliferation, differentiation, and survival, the most prominent features of cancer cells.
In this Research Topic, we aim to focus on the key roles that lipids can play in all aspects of cancer, including trials and potential therapeutic application. We will address the current knowledge of lipids in all aspects of cancer and we welcome studies that focus on but are not limited to:
1. Lipid metabolism in cancer: synthesis, degradation, uptake, storage, utilization, oxidation, and peroxidation (for example, oxysterols, eicosanoids, oxidized LDL, oxidative stress), lipolysis, membrane biogenesis, key enzymes, receptors, signal transduction, gene expression, metabolic reprogramming.
2. The role of lipids in cancer: cell proliferation, cell differentiation, cell death (ferroptosis, apoptosis, etc), cancer cell survival, cancer stem cells, cell transformation, cancer progression, angiogenesis, cancer relapse, immune responsiveness, chemoresistance, metastasis, therapy
All types of contributions presenting new unpublished data or reviewing available information are welcome: Original Articles, Reviews, Systematic Reviews, Clinical Trials.
Please note: manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in any of the sections of Frontiers in Oncology.
Keywords: Lipid, cancer, oxidation, oxidative stress, free fatty acid, cholesterol, oxysterols, sphingolipids, eicosanoids, cancer stem cell, cell death, cell proliferation, apoptosis, ferroptosis, pyroptosis, autophagy, immune cells, oncogenes, cancer signaling pathways, metabolic reprogramming, metastasis.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
