Vascular and Skeletal Crosstalk in Health and Disease

The vascular and skeletal systems are tightly connected, interacting both physically and through the secretion of growth factors. Angiogenesis and osteogenesis are tightly linked during bone development, pathology, and repair. The pathologies of bone disease are multifactorial and certain aspects might lie in the bone vasculature. The bone vasculature is organized in distinct vessel subtypes that differentially regulate osteogenesis, hematopoiesis, and osteopathologies.

Osteopatholigies might derive a portion of its etiology from several vascular dysfunctions, which may rest internal to the skeleton or external. Proper regulation of the bone vascular network is vital to a healthy skeleton and unbalances may contribute to osteopathologies.

This Research Topic aims at collecting manuscripts on the mechanisms of interaction between bone and vascular systems, and how this influences bone mass and remodeling in health and diseases. Themes of interest include, but are not limited to:

- The effect of blood dysregulations and bone diseases

- Bone and vascular systems interdependence

- Bone perfusion and the regulation of blood flow to the skeleton

- Angiogenesis/osteogenesis regulation

- Blood vessel morphology, location, and calcification