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About this Research Topic

Manuscript Submission Deadline 11 November 2022
Manuscript Extension Submission Deadline 16 December 2022

Urinary tract infections (UTIs) are among the most common bacterial infections, resulting in millions of physician visits annually. There are many forms of UTIs, both acute and chronic, each with its own unique challenges for both the bacteria and the host. The innate immune response is the first line of defense against an invading pathogen and performs a complex balancing act between acute inflammation and pathogen elimination without damaging the host. Many previous studies have shown that the urinary epithelium and innate immune cells like neutrophils and macrophages work in concert through the detection of PAMPs and DAMPs, followed by the secretion of a wide variety of chemokines, cytokines, and antimicrobial peptides in order to detect pathogens and recruit cells to the infected area for pathogen elimination. Dysregulation of the immune response can lead to chronic infection and host tissue damage. In addition, the pathogen works to evade detection by the host through both physical means (IBC formation, filamentation), and through immune modulation by inhibiting cytokine production or immune cell recruitment.



Although the innate immune response to UTIs has been studied consistently for many years, we are still far from understanding the complex interplay between the host response and immune modulation and evasion by the infecting pathogen. A more complete understanding of these processes will allow us to move closer to more effective therapies for UTIs in the future.



We welcome authors to contribute with articles on these specific topics of interest are:

• Further investigation of immune modulation by urinary pathogens in cystitis, pyelonephritis, or Catheter-Associated Urinary Tract Infections (CAUTI)

• Further characterization of the innate immune response in cystitis, pyelonephritis, or CAUTI

• Sex differences in the innate immune response to UTI

• Determination of specific innate immune host factors and cell types and their involvement in pathogen detection and elimination

• Determination of new therapies that augment the innate immune response to UTIs

• Determination of how innate immune dysregulation occurs in UTIs and models of how to prevent/repair the resulting host tissue damage

• Investigation of host genetic factors that predispose to urinary tract colonization and infection due to innate immune dysregulation

• Determination of new antibiotic-sparing therapies that prevent UTIs

Keywords: UTIs, innate immunity, new therapies, bacterial infections, immune dysregulation


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Urinary tract infections (UTIs) are among the most common bacterial infections, resulting in millions of physician visits annually. There are many forms of UTIs, both acute and chronic, each with its own unique challenges for both the bacteria and the host. The innate immune response is the first line of defense against an invading pathogen and performs a complex balancing act between acute inflammation and pathogen elimination without damaging the host. Many previous studies have shown that the urinary epithelium and innate immune cells like neutrophils and macrophages work in concert through the detection of PAMPs and DAMPs, followed by the secretion of a wide variety of chemokines, cytokines, and antimicrobial peptides in order to detect pathogens and recruit cells to the infected area for pathogen elimination. Dysregulation of the immune response can lead to chronic infection and host tissue damage. In addition, the pathogen works to evade detection by the host through both physical means (IBC formation, filamentation), and through immune modulation by inhibiting cytokine production or immune cell recruitment.



Although the innate immune response to UTIs has been studied consistently for many years, we are still far from understanding the complex interplay between the host response and immune modulation and evasion by the infecting pathogen. A more complete understanding of these processes will allow us to move closer to more effective therapies for UTIs in the future.



We welcome authors to contribute with articles on these specific topics of interest are:

• Further investigation of immune modulation by urinary pathogens in cystitis, pyelonephritis, or Catheter-Associated Urinary Tract Infections (CAUTI)

• Further characterization of the innate immune response in cystitis, pyelonephritis, or CAUTI

• Sex differences in the innate immune response to UTI

• Determination of specific innate immune host factors and cell types and their involvement in pathogen detection and elimination

• Determination of new therapies that augment the innate immune response to UTIs

• Determination of how innate immune dysregulation occurs in UTIs and models of how to prevent/repair the resulting host tissue damage

• Investigation of host genetic factors that predispose to urinary tract colonization and infection due to innate immune dysregulation

• Determination of new antibiotic-sparing therapies that prevent UTIs

Keywords: UTIs, innate immunity, new therapies, bacterial infections, immune dysregulation


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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