About this Research Topic
There is an increasing need to characterize gene expression in isolated cells, with a single-cell approach, to better understand the changes that underlie the development of new clones in the field of human health and aging. Numerous investigations concern the expression of coding genes associated with heterogeneity and clonogenicity in the development and progression of human diseases, especially cancer. In this context, the dysregulation of non-coding RNAs could represent a crucial step in defining their regulatory roles. This approach can be developed as a tool to further understand molecular networks and identify new therapeutic targets.
The aim of this present Research Topic is to focus on some of the discovered and prevalent non-coding RNAs in order to illuminate their characterization and knowledge of their regulatory functions. This is especially important from the perspective of molecular alterations that impact single cells in a wide range of pathologies and aging processes.
This Research Topic welcomes manuscripts showcasing the latest advances in the research field of the non-coding RNAs (miRNA, T-UCR, circular RNA, enhancers, and so on…) from the point of view of single-cell studies. We are interested in Original Research, Reviews, and other article types focusing on but not limited to, the following topics:
• Advances in bioinformatics technologies and strategies applied to single-cell sequencing
• Epigenetic modifications and non-coding RNA expression
• Mutations and dysregulation of non-coding RNA in human disease and aging
• Relationships and networks between coding RNAs and non-coding RNAs
• Single-cell imaging
• Single-cell and applied therapeutic strategies
The aim of this present Research Topic is to focus on some of the discovered and prevalent non-coding RNAs in order to illuminate their characterization and knowledge of their regulatory functions. This is especially important from the perspective of molecular alterations that impact single cells in a wide range of pathologies and aging processes.
This Research Topic welcomes manuscripts showcasing the latest advances in the research field of the non-coding RNAs (miRNA, T-UCR, circular RNA, enhancers, and so on…) from the point of view of single-cell studies. We are interested in Original Research, Reviews, and other article types focusing on but not limited to, the following topics:
• Advances in bioinformatics technologies and strategies applied to single-cell sequencing
• Epigenetic modifications and non-coding RNA expression
• Mutations and dysregulation of non-coding RNA in human disease and aging
• Relationships and networks between coding RNAs and non-coding RNAs
• Single-cell imaging
• Single-cell and applied therapeutic strategies
Keywords: ncRNA, non-coding RNA, Single-Cell, Expression, Imaging, Therapeutics
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
