About this Research Topic

Manuscript Submission Deadline 20 October 2022

Due to the heterogeneous nature of pediatric cardiovascular illnesses, pediatric heart failure has substantial differences in patient profiles and mechanisms compared with adults. Even with the same etiology, there are still differences in the pathogenesis of HF in children and adults. For example, the impairment of β-adrenergic receptor subtypes in the process of heart failure caused by dilated cardiomyopathy in children is not identical as it is with adults. Besides, the embryonic heart is significantly different from the adult heart in terms of energy metabolism, myofilament protein subtypes, and ion channel protein subtypes. There is yet little research about how energy metabolism, myofilament protein isoforms, ion channel proteins, and calcium ion regulatory pathways play their roles in the process of HF in children and how is the process different from HF in adults. Additionally, neurohumoral regulation in children also differs from adults due to the effect of developmental processes.

Although the survival rate of children with heart failure has significantly improved with the development and advances in the diagnosis and management, heart failure is still the major problem endangering children’s life and health. More research and clinical studies are needed to generate evidence-based therapies for critically ill children with heart failure and avoiding blindly adhibition of “scientific research achievements” of adults’ HF in children.

This Research Topic aims to focus on heart failure in pediatric population. The research of pediatric heart failure has fallen behind compared with that in adult patients, especially in pathophysiology, mechanism and treatment. More evidence-based research is needed to generate consensus and guidelines for the improvement of outcomes of pediatric heart failure.

We welcome original research and review articles focusing on the following subtopics including but not limited to:
1. The mechanism of heart failure in children with co-morbidities such as dilated cardiomyopathy, congenital heart disease, and other diseases.
2. The current challenge of therapy for heart failure in children with co-morbidities such as dilated cardiomyopathy, congential heart disease, and other diseases.
3. Pediatric mechanical circulatory support (MCS) for heart failure in children.
4. Pediatric heart transplantation and heart-lung transplantation for heart failure in children.

Keywords: Pediatric, Heart failure, Mechanical circulatory support, heart transplantation, heart-lung transplantation


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Due to the heterogeneous nature of pediatric cardiovascular illnesses, pediatric heart failure has substantial differences in patient profiles and mechanisms compared with adults. Even with the same etiology, there are still differences in the pathogenesis of HF in children and adults. For example, the impairment of β-adrenergic receptor subtypes in the process of heart failure caused by dilated cardiomyopathy in children is not identical as it is with adults. Besides, the embryonic heart is significantly different from the adult heart in terms of energy metabolism, myofilament protein subtypes, and ion channel protein subtypes. There is yet little research about how energy metabolism, myofilament protein isoforms, ion channel proteins, and calcium ion regulatory pathways play their roles in the process of HF in children and how is the process different from HF in adults. Additionally, neurohumoral regulation in children also differs from adults due to the effect of developmental processes.

Although the survival rate of children with heart failure has significantly improved with the development and advances in the diagnosis and management, heart failure is still the major problem endangering children’s life and health. More research and clinical studies are needed to generate evidence-based therapies for critically ill children with heart failure and avoiding blindly adhibition of “scientific research achievements” of adults’ HF in children.

This Research Topic aims to focus on heart failure in pediatric population. The research of pediatric heart failure has fallen behind compared with that in adult patients, especially in pathophysiology, mechanism and treatment. More evidence-based research is needed to generate consensus and guidelines for the improvement of outcomes of pediatric heart failure.

We welcome original research and review articles focusing on the following subtopics including but not limited to:
1. The mechanism of heart failure in children with co-morbidities such as dilated cardiomyopathy, congenital heart disease, and other diseases.
2. The current challenge of therapy for heart failure in children with co-morbidities such as dilated cardiomyopathy, congential heart disease, and other diseases.
3. Pediatric mechanical circulatory support (MCS) for heart failure in children.
4. Pediatric heart transplantation and heart-lung transplantation for heart failure in children.

Keywords: Pediatric, Heart failure, Mechanical circulatory support, heart transplantation, heart-lung transplantation


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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