Research Topic

Functional and structural changes in Mild Cognitive Impairment

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Dementia is one of the neurodegenerative diseases that produce the greater disability and dependency in the elderly population worldwide. It is estimated that 60-70% of cases of dementia are due to Alzheimer's disease (AD), for which there is still no cure. The impact of cognitive, physical, psychological, ...

Dementia is one of the neurodegenerative diseases that produce the greater disability and dependency in the elderly population worldwide. It is estimated that 60-70% of cases of dementia are due to Alzheimer's disease (AD), for which there is still no cure. The impact of cognitive, physical, psychological, social and economic level that this upset has on the patient, their caregivers and the general society make it a priority for the scientific community worldwide.


Therefore, there are many research focused on the study of the initial stages of this disease that try to shed light on the factors that predispose to undergo it, and those which can help to slow or reverse its effects, being their ultimate goal to improve the quality of life of those people who suffer it.


Mild cognitive impairment (MCI) is considered an intermediate state between normal aging and dementia, mainly Alzheimer´s type. Its research is essential to characterize the first manifestations of the disease, which usually affect the episodic memory, and to explore and predict its evolution. Currently, there are varied and numerous approaches from being addressed the study of MCI, which is helping to have an increasingly deep understanding of this pathological condition and therefore the AD. Nevertheless, there are many questions today that are still unanswered.

This Frontiers Research Topic is focused on the study of MCI based both structural and functional neuroimaging techniques, such as: Magnetic Resonance (MR), functional RM (fRM), Electroencephalogram (EEG), Magnetoencephalography (MEG), positron emission tomography (PET)… to explore how the information from these different techniques may support the current diagnostic criteria, if it would be possible to incorporate some of them as biomarker of the disease and finally to promote a global approach of this entity.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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