About this Research Topic
Pituitary disorders may be associated with an increased risk of cardiovascular and metabolic complications and, in consequence, increased mortality. Excessive secretion of pituitary hormones provokes functional and systemic abnormalities which can be manifested by cardiovascular complications such as eg. arterial hypertension, heart failure, arrhythmia, as through metabolic disturbances, including obesity and diabetes.
Subclinical effects of pituitary diseases, such as cardiac and vascular dysfunction, also modifies prognosis but due to its asymptomatic course are frequently diagnosed with significant time delay. Even successful surgery and pharmacological treatment of pituitary disorders do not guarantee that metabolic and cardiovascular comorbidities can be completely resolved after primary disease remission.
This Research Topic aims to provide insights into the cross-talk between pituitary and cardiometabolic disorders in respect to effective diagnosis and targeted therapy. We also especially welcome studies that advance our knowledge on molecular mechanisms and pathogenic pathways explaining these phenomena.
Another issue that still needs clarification is an effective model of interdisciplinary care focused on holistic approach to patients with pituitary disorders. We would like to turn on a light of attention towards the importance of psychological, dietary, and rehabilitation care. We aim to collect the up-to-date studies presenting novel results and future perspectives in this area.
In this Research Topic, we welcome the submission of original research, reviews, and expert opinions, that include but are not limited to the following areas in pituitary disorders:
• prevalence of cardiovascular and metabolic comorbidities
• molecular mechanisms and pathogenic pathways of cardiovascular and metabolic complications
• novel diagnostic tools and biochemical markers to detect early cardiovascular and metabolic complications
• individualized treatment of cardiovascular and metabolic complications
• reversibility of cardiovascular and metabolic abnormalities after biochemical control of primary endocrine dysfunction
• optimal model of interdisciplinary care
• diet, psychological support, rehabilitation
Subclinical effects of pituitary diseases, such as cardiac and vascular dysfunction, also modifies prognosis but due to its asymptomatic course are frequently diagnosed with significant time delay. Even successful surgery and pharmacological treatment of pituitary disorders do not guarantee that metabolic and cardiovascular comorbidities can be completely resolved after primary disease remission.
This Research Topic aims to provide insights into the cross-talk between pituitary and cardiometabolic disorders in respect to effective diagnosis and targeted therapy. We also especially welcome studies that advance our knowledge on molecular mechanisms and pathogenic pathways explaining these phenomena.
Another issue that still needs clarification is an effective model of interdisciplinary care focused on holistic approach to patients with pituitary disorders. We would like to turn on a light of attention towards the importance of psychological, dietary, and rehabilitation care. We aim to collect the up-to-date studies presenting novel results and future perspectives in this area.
In this Research Topic, we welcome the submission of original research, reviews, and expert opinions, that include but are not limited to the following areas in pituitary disorders:
• prevalence of cardiovascular and metabolic comorbidities
• molecular mechanisms and pathogenic pathways of cardiovascular and metabolic complications
• novel diagnostic tools and biochemical markers to detect early cardiovascular and metabolic complications
• individualized treatment of cardiovascular and metabolic complications
• reversibility of cardiovascular and metabolic abnormalities after biochemical control of primary endocrine dysfunction
• optimal model of interdisciplinary care
• diet, psychological support, rehabilitation
Keywords: pituitary disease, Cushing’s disease, acromegaly, prolactinoma, cardiovascular complications, metabolic complications
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