Since high resolution single cell multiomics techniques have become widely available, extensive documentation, both theoretical and experimental, of the heterogeneity of cellular systems is now well accepted. Cellular heterogeneity can be measured in several different ways, most commonly via genomic, epigenomic, transcriptomic, and proteomic studies. As multiomics approaches are unearthing heterogeneity at the cellular level, it is becoming increasingly important to determine the physiological significance of this diversity.
Does the heterogeneity documented in multiomics datasets lead to functional diversity in cells and how do distinct cell types with unique expression profiles contribute to tissue homeostasis and disease? The answers to such questions should provide incredible insight into the physiological and pathophysiological regulation of tissues throughout the human body.
This Research Topic will include, reviews and research articles focusing on the identification and functional characterization of heterogeneity in cells. Given the extensive cellular heterogeneity in cancer, articles focusing solely on cancer will not be included in the scope of the collection.
Since high resolution single cell multiomics techniques have become widely available, extensive documentation, both theoretical and experimental, of the heterogeneity of cellular systems is now well accepted. Cellular heterogeneity can be measured in several different ways, most commonly via genomic, epigenomic, transcriptomic, and proteomic studies. As multiomics approaches are unearthing heterogeneity at the cellular level, it is becoming increasingly important to determine the physiological significance of this diversity.
Does the heterogeneity documented in multiomics datasets lead to functional diversity in cells and how do distinct cell types with unique expression profiles contribute to tissue homeostasis and disease? The answers to such questions should provide incredible insight into the physiological and pathophysiological regulation of tissues throughout the human body.
This Research Topic will include, reviews and research articles focusing on the identification and functional characterization of heterogeneity in cells. Given the extensive cellular heterogeneity in cancer, articles focusing solely on cancer will not be included in the scope of the collection.
