Ultrasound neuromodulation is a young technology which is considered as a next generation approach for probing brain functions and treating brain diseases. It holds great potential in both preclinical studies and clinical applications. It has the unique advantages of non-invasiveness, high spatiotemporal resolution, and the capability for deep brain targeting. Recent years witnessed rapid advances in understanding the mechanisms of ultrasound neuromodulation and translating novel applications from animal models (rodent, large animal and non-human primates) to humans, covering both central and peripheral nervous systems.
This field is evolving quickly with many interesting ongoing studies. To promote its clinical translation, clearer knowledge of the mechanisms, better control and monitoring of the modulation outcomes, and systems for human use are in urgent need.
Thus, in this research topic, we would like to address some of the major ongoing studies on biophysical mechanisms, novel methods for targeting specific neurons through turing parameters or using sonogenetics/sonothermogenetics, applications in animal models and translational studies. We welcome submissions in the form of original research, systematic reviews, methods articles, and opinion articles.
Areas of focus can include but are not limited to:
·Biophysical cellular mechanisms, e.g., on ion channels, membrane deformation, cytoskeleton etc.
·Probing brain function and treating brain diseases in human and animal models
·Sonogenetics/sonothermogenetics
· Microbubbles/nanobubbles (and other nanoscale particles) mediated/enhanced ultrasound neuromodulation
· Ultrasound modulation applications in CNS and PNS
· Novel findings
· Possible confound
· Safety
· Theoretical Models
· Novel systems for prelinical and clinical application
· Comparison/combination with other neuromodulation approaches
·Strategies for transmitting ultrasound through the skull
·Effects of ultrasound on brain plasticity
Ultrasound neuromodulation is a young technology which is considered as a next generation approach for probing brain functions and treating brain diseases. It holds great potential in both preclinical studies and clinical applications. It has the unique advantages of non-invasiveness, high spatiotemporal resolution, and the capability for deep brain targeting. Recent years witnessed rapid advances in understanding the mechanisms of ultrasound neuromodulation and translating novel applications from animal models (rodent, large animal and non-human primates) to humans, covering both central and peripheral nervous systems.
This field is evolving quickly with many interesting ongoing studies. To promote its clinical translation, clearer knowledge of the mechanisms, better control and monitoring of the modulation outcomes, and systems for human use are in urgent need.
Thus, in this research topic, we would like to address some of the major ongoing studies on biophysical mechanisms, novel methods for targeting specific neurons through turing parameters or using sonogenetics/sonothermogenetics, applications in animal models and translational studies. We welcome submissions in the form of original research, systematic reviews, methods articles, and opinion articles.
Areas of focus can include but are not limited to:
·Biophysical cellular mechanisms, e.g., on ion channels, membrane deformation, cytoskeleton etc.
·Probing brain function and treating brain diseases in human and animal models
·Sonogenetics/sonothermogenetics
· Microbubbles/nanobubbles (and other nanoscale particles) mediated/enhanced ultrasound neuromodulation
· Ultrasound modulation applications in CNS and PNS
· Novel findings
· Possible confound
· Safety
· Theoretical Models
· Novel systems for prelinical and clinical application
· Comparison/combination with other neuromodulation approaches
·Strategies for transmitting ultrasound through the skull
·Effects of ultrasound on brain plasticity
