Increasing evidence suggests that microbial communities and their cellular and molecular components, and microbial metabolites are intimately linked to human health and in particular, are known to provide key signals for the development and functioning of the immune system. Disruption of the fine-tuned equilibrium among the microbial communities has been implicated in a range of diseases such as metabolic, neuropsychiatric, inflammatory diseases and many others. Although the advent of next-generation sequencing technologies that can profile microbial communities at gene-level has advanced microbiome research dramatically in recent years, mechanisms linking the microbiome to human health and disease are critically lacking. Towards that end, microbial metabolites that are key mediators of microbial interactions, as well as host-microorganism interactions are of great interest for decoding the mechanisms of these co-metabolic interactions in human health and disease at the molecular level for novel therapeutic targets.
This Research Topic aims to highlight the application of multi-omic methods for probing the microbiome, microbial mutualism with an emphasis on microbiota associated small-molecule metabolites, in conjunction with the immune system to gain mechanistic insights into host-microbiota interactions. This will lead to the discovery of more microbiome-based biomarkers and indicate microbiome-based interventions that are relevant to immune system function.
We welcome the submissions of Original Research, Review, Mini-Review, Perspectives and Technology and Code articles focusing on, but not limited to, the following sub-topics:
• the application of 16S rRNA phylogenetic marker and shotgun metagenomic or metatranscriptomic sequencing of oral or gut microbiome
• mass spectrometry-based metabolomics, metaproteomics and host inflammatory pathway analysis to better understand the molecular interactions between the human microbiota and the host metabolism, particularly in health versus disease conditions.
Increasing evidence suggests that microbial communities and their cellular and molecular components, and microbial metabolites are intimately linked to human health and in particular, are known to provide key signals for the development and functioning of the immune system. Disruption of the fine-tuned equilibrium among the microbial communities has been implicated in a range of diseases such as metabolic, neuropsychiatric, inflammatory diseases and many others. Although the advent of next-generation sequencing technologies that can profile microbial communities at gene-level has advanced microbiome research dramatically in recent years, mechanisms linking the microbiome to human health and disease are critically lacking. Towards that end, microbial metabolites that are key mediators of microbial interactions, as well as host-microorganism interactions are of great interest for decoding the mechanisms of these co-metabolic interactions in human health and disease at the molecular level for novel therapeutic targets.
This Research Topic aims to highlight the application of multi-omic methods for probing the microbiome, microbial mutualism with an emphasis on microbiota associated small-molecule metabolites, in conjunction with the immune system to gain mechanistic insights into host-microbiota interactions. This will lead to the discovery of more microbiome-based biomarkers and indicate microbiome-based interventions that are relevant to immune system function.
We welcome the submissions of Original Research, Review, Mini-Review, Perspectives and Technology and Code articles focusing on, but not limited to, the following sub-topics:
• the application of 16S rRNA phylogenetic marker and shotgun metagenomic or metatranscriptomic sequencing of oral or gut microbiome
• mass spectrometry-based metabolomics, metaproteomics and host inflammatory pathway analysis to better understand the molecular interactions between the human microbiota and the host metabolism, particularly in health versus disease conditions.
