About this Research Topic
Life expectancy has been increasing in the world since the beginning of the 20th century regardless of the socioeconomic status of the country. This resulted in a larger proportion of older patients and increasing incidence of age-related diseases such as hypertension, type 2 diabetes and Alzheimer’s disease. Therefore, the need for finding new additional biomarkers for assessment of age-related diseases is becoming increasingly apparent.
These additional biomarkers could improve early detection of the diseases associated with aging, enhance stratification of the patients according to the risk for development of complications, and help better evaluation of the therapeutic outcomes.
Numerous validated non-invasive biomarkers follow the theory of accelerated vascular aging. For example, at the macrovascular level, aging causes increased arterial stiffness, which is accelerated by hypertension. This can be assessed by measuring carotid-femoral and brachial-ankle pulse wave velocity. However, there is a growing evidence that this increase in stiffness is caused by changes in mechanical properties of extracellular matrix and by smooth muscle cell phenotypic modulation. Together, they cause specific expression patterns of circulating micro-RNAs, new potential biomarkers of vascular remodeling. At the capillary level, aging causes decreased complexity of microvascular network, a process accelerated in the presence of aging-related disease. Recent advances in medical imaging, telematic data collection, and artificial intelligence application may lead to identification of unique microvascular patterns, that could serve as biomarkers for assessment of cardiovascular risk or dementia.
The goal of this Research Topic is to gather and showcase multidisciplinary research focused on identification of new non-invasive putative biomarkers that could improve assessment of aging-related diseases.
We welcome submissions that investigate vascular physiology in aging, biomarkers for aging-related diseases based on changes in macro and microvascular structure and function, as well as novel circulatory biomarkers related to vascular aging. Recommended publication types are original research, review, method, hypothesis and theory, data report, and technology and code.
Keywords: vascular aging, noninvasive biomarkers, age-related diseases, vascular stiffness, microvascular geometry, vascular imaging, vascular remodeling, microcirculation
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