Several discoveries have been made with genome-wide or candidate gene approaches that have revealed significant insights into host gene and immune interactions. As a result, there is a growing appreciation for immunogenomics, the interconnected relation between genomics and the immune environment. On the other side, specific human gene variants that contribute to enhanced susceptibility or resistance against several diseases have been identified. These genes profoundly affect other gene expression in disease onset or/and progression. Target genes that transcribe both coding and non-coding RNA are involved in regulating several biological processes such as cell division, differentiation, cell death, and multiple signalling pathways. Noncoding RNAs have emerged as a multifunctional regulator in several diseases. Several studies have unravelled associations between aberrant noncoding RNA expression and pathologies of human diseases. These associations have been extensively reviewed, often with the focus on a particular microRNA (miRNA) (family) or a selected disease/pathology. In addition, multiple non-coding RNAs modulate the expression patterns of multiple genes, which play important roles in different diseases. Like other non-coding RNAs, circRNAs have been found to play role in gene regulation via interaction with other biomolecules like nucleic acids, proteins and microRNAs (miRNAs). Recently, circular RNAs (circRNAs) which are both abundant and physiologically stable have received a great deal of attention as potential molecular biomarkers. Indeed, it has been reported that circulating and/or tissue-specific circRNAs can be used for diagnosing multiple human diseases, including cancers, neurological diseases, and inflammatory diseases.
Several specific genes regulate immunomodulatory molecules such as IL2, IL3, miR-34a, and miR-17-92. Furthermore, some molecules regulate immune responses by interacting with molecules related to the immune response either directly or via regulating other molecules. Thus, these genes connect the immunomodulatory pathways and shift the pro-inflammatory balance towards the pro-diseases condition. Thus, the role of immunogenomics in different diseases has been gaining particular attention in recent decades in the scientific world. Recently, advances in genome editing technology are making it possible to reprogram the specificity and function of innate/ adaptive immune cells, which leads to promise of generating “pharmacological targets” that can respond to reprogramed immune cells in disease conditions like autoimmunity (type 1 diabetes, thyroid autoimmunity, Crohn’s disease), inflammatory diseases (Alzheimer’s, Parkinson, Dementia) or in cancer.
In this Research Topic, we will concentrate on collecting latest updates about the role of different genes in multiple diseases. Also, we highlight the regulatory function of the different genes in the progression or suppression of diseases and the targeting of these genes as a potential therapeutic approach for disease management. We anticipate that our Research Topic will contribute to expanding the research community's knowledge about this recent and rapidly growing field of Genes, Diseases, and immunity for a further thorough investigation, which will surely help manage multiple deadly diseases.
Topics of interest include but are not limited to:
• Role of Gene/s in disease biology.
• Genes-noncoding RNA-Immunity Circuity in disease
• Role of Trancription Factors in Diseases
• Role of noncoding RNAs in the Disease.
• Interaction between Immunomodulatory molecules with other genes/gene products
• Reprogramming of immune cells
Several discoveries have been made with genome-wide or candidate gene approaches that have revealed significant insights into host gene and immune interactions. As a result, there is a growing appreciation for immunogenomics, the interconnected relation between genomics and the immune environment. On the other side, specific human gene variants that contribute to enhanced susceptibility or resistance against several diseases have been identified. These genes profoundly affect other gene expression in disease onset or/and progression. Target genes that transcribe both coding and non-coding RNA are involved in regulating several biological processes such as cell division, differentiation, cell death, and multiple signalling pathways. Noncoding RNAs have emerged as a multifunctional regulator in several diseases. Several studies have unravelled associations between aberrant noncoding RNA expression and pathologies of human diseases. These associations have been extensively reviewed, often with the focus on a particular microRNA (miRNA) (family) or a selected disease/pathology. In addition, multiple non-coding RNAs modulate the expression patterns of multiple genes, which play important roles in different diseases. Like other non-coding RNAs, circRNAs have been found to play role in gene regulation via interaction with other biomolecules like nucleic acids, proteins and microRNAs (miRNAs). Recently, circular RNAs (circRNAs) which are both abundant and physiologically stable have received a great deal of attention as potential molecular biomarkers. Indeed, it has been reported that circulating and/or tissue-specific circRNAs can be used for diagnosing multiple human diseases, including cancers, neurological diseases, and inflammatory diseases.
Several specific genes regulate immunomodulatory molecules such as IL2, IL3, miR-34a, and miR-17-92. Furthermore, some molecules regulate immune responses by interacting with molecules related to the immune response either directly or via regulating other molecules. Thus, these genes connect the immunomodulatory pathways and shift the pro-inflammatory balance towards the pro-diseases condition. Thus, the role of immunogenomics in different diseases has been gaining particular attention in recent decades in the scientific world. Recently, advances in genome editing technology are making it possible to reprogram the specificity and function of innate/ adaptive immune cells, which leads to promise of generating “pharmacological targets” that can respond to reprogramed immune cells in disease conditions like autoimmunity (type 1 diabetes, thyroid autoimmunity, Crohn’s disease), inflammatory diseases (Alzheimer’s, Parkinson, Dementia) or in cancer.
In this Research Topic, we will concentrate on collecting latest updates about the role of different genes in multiple diseases. Also, we highlight the regulatory function of the different genes in the progression or suppression of diseases and the targeting of these genes as a potential therapeutic approach for disease management. We anticipate that our Research Topic will contribute to expanding the research community's knowledge about this recent and rapidly growing field of Genes, Diseases, and immunity for a further thorough investigation, which will surely help manage multiple deadly diseases.
Topics of interest include but are not limited to:
• Role of Gene/s in disease biology.
• Genes-noncoding RNA-Immunity Circuity in disease
• Role of Trancription Factors in Diseases
• Role of noncoding RNAs in the Disease.
• Interaction between Immunomodulatory molecules with other genes/gene products
• Reprogramming of immune cells