About this Research Topic
The gene regulatory networks of cardiac enriched transcription factors and their target genes play an important role in the pathophysiology of arrhythmogenesis. Transcription factors bind to the promoter regions of target genes and regulate the expression of genes involved in cardiac structures and development of the cardiac conduction system. Transcription factors are supposed to regulate arrhythmogenesis via their effects on calcium homeostasis, ionic currents, inflammation, oxidative stress, or structure remodeling.
In this Research Topic, we aim to provide a communication platform for interdisciplinary researchers to address the most recent work on transcription factors in arrhythmogenesis regulation, as well as their role in non-myocytes and the potential of transcription factors targeting as a new treatment option for arrhythmogenesis. Articles with an in depth focus on transcription factor mutation and arrhythmogenesis and the design of therapeutic strategies tailored to halt the myocardium from transcription factors loss or gain of function-induced deterioration are welcomed. The pathophysiological remodeling of the cardiovascular system in dysregulation of transcription factors and their influence on cardiac function are also of interest to the Topic, as well as manuscripts dealing with the identification of cardiac arrhythmia biomarkers for early detection of myocardial dysfunction and prevention of their arrhythmogenesis in dysregulated transcription factors in patients.
We welcome Original Research, Reviews and other article types. We expect submissions relating, but not limited, to the following themes:
- Cellular electrophysiology of gene variants of transcription factor related arrhythmogenesis
- Molecular mechanisms or pathogenesis of arrhythmogenesis related to dysregulation of transcription factors.
- Translational researches of dysregulated transcription factors associated arrhythmogenesis
- Cardiac metabolism, structural remodeling, and mitochondrial function in transcription factors dysregulation related arrhythmogenesis
- Novel biomarkers, therapeutic strategy of transcription regulators, or other risk genes of arrhythmia from genome-wide association studies
In this Research Topic, we aim to provide a communication platform for interdisciplinary researchers to address the most recent work on transcription factors in arrhythmogenesis regulation, as well as their role in non-myocytes and the potential of transcription factors targeting as a new treatment option for arrhythmogenesis. Articles with an in depth focus on transcription factor mutation and arrhythmogenesis and the design of therapeutic strategies tailored to halt the myocardium from transcription factors loss or gain of function-induced deterioration are welcomed. The pathophysiological remodeling of the cardiovascular system in dysregulation of transcription factors and their influence on cardiac function are also of interest to the Topic, as well as manuscripts dealing with the identification of cardiac arrhythmia biomarkers for early detection of myocardial dysfunction and prevention of their arrhythmogenesis in dysregulated transcription factors in patients.
We welcome Original Research, Reviews and other article types. We expect submissions relating, but not limited, to the following themes:
- Cellular electrophysiology of gene variants of transcription factor related arrhythmogenesis
- Molecular mechanisms or pathogenesis of arrhythmogenesis related to dysregulation of transcription factors.
- Translational researches of dysregulated transcription factors associated arrhythmogenesis
- Cardiac metabolism, structural remodeling, and mitochondrial function in transcription factors dysregulation related arrhythmogenesis
- Novel biomarkers, therapeutic strategy of transcription regulators, or other risk genes of arrhythmia from genome-wide association studies
Keywords: Arrhythmogenesis, Calcium Homeostasis, Cardiac Electrophysiology, Cardiac Metabolism, Inflammatory Signaling, Transcription Factor
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
