Research Topic

Organogenesis: from development to disease

About this Research Topic

During embryonic development there are many processes that must take place to produce a viable and healthy fetus. Alterations in the cellular and/or molecular interactions within any particular organ can cause catastrophic defects leading to defective organogenesis and death of the embryo. Even slight ...

During embryonic development there are many processes that must take place to produce a viable and healthy fetus. Alterations in the cellular and/or molecular interactions within any particular organ can cause catastrophic defects leading to defective organogenesis and death of the embryo. Even slight malformations of the organs can cause developmental reprogramming and increase the likelihood of adult onset diseases. The use of experimental animals with genetic mutations that mimic many human conditions has lead to significant scientific advancement of these complex and multifaceted diseases. Furthermore, the utilization of organ culture systems has made for profound insights into the formation of organs. Over recent years, the technology related to molecular profiling and imaging of developing organs has dramatically improved, leading to the identification of subtle genetic and phenotypic alterations. This research topic will focus on the area of organ formation and modeling of human developmental diseases.

Areas of interest for this research topic include but are not limited to:
• Organ formation: normal and abnormal
• Model organisms to model genetic malformations of the organs
• Organ culture
• Fetal organ reprogramming
• Advances in imaging of organ formation
• Advances in profiling of organ formation and disease
• New technologies to manipulate organ formation
• Experimental animal models to mimic human disease


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