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“A year in review: Discussions in Primary Immunodeficiencies” is part of a wider series of Research Topics across Frontiers in Immunology, hosted by our Speciality Chief Editors.



This Research Topic aims to spark discussion around popular spontaneous articles from 2021 in Primary ...

“A year in review: Discussions in Primary Immunodeficiencies” is part of a wider series of Research Topics across Frontiers in Immunology, hosted by our Speciality Chief Editors.



This Research Topic aims to spark discussion around popular spontaneous articles from 2021 in Primary Immunodeficiencies. The Primary Immunodeficiencies field is continuously evolving, therefore we are seeking to understand developments and perspectives on articles that have attracted attention throughout the year.



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The chosen manuscripts are :

Reactive T Cells in Convalescent COVID-19 Patients With Negative SARS-CoV-2 Antibody Serology

Genetic Screening for TLR7 Variants in Young and Previously Healthy Men With Severe COVID-19

Transcriptional Profiling of STAT1 Gain-of-Function Reveals Common and Mutation-Specific Fingerprints

SARS-CoV-2 Spike Protein-Directed Monoclonal Antibodies May Ameliorate COVID-19 Complications in APECED Patients


A Pathogenic Missense Variant in NFKB1 Causes Common Variable Immunodeficiency Due to Detrimental Protein Damage


Common Variable Immunodeficiency and Autoimmune Diseases: A Retrospective Study of 95 Adult Patients in a Single Tertiary Care Center


Patients With Common Variable Immunodeficiency (CVID) Show Higher Gut Bacterial Diversity and Levels of Low-Abundance Genes Than the Healthy Housemates

Novel Discoveries in Immune Dysregulation in Inborn Errors of Immunity

Immune Dysregulation in IgG4-Related Disease

Real-World Experiences With Facilitated Subcutaneous Immunoglobulin Substitution in Patients With Hypogammaglobulinemia, Using a Three-Step Ramp-Up Schedule




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This topic will be summarized by the specialty chief editors in an editorial alongside their vision for Primary Immunodeficiencies.



We welcome Opinions, Perspectives, Hypotheses and Theory, and Mini-Review article types to facilitate this discussion. Please note only papers that are relevant and add a significant contribution to the discussion articles will be considered.

Keywords: A year in review: Discussions in Primary Immunodeficiencies


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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