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Malignant cancers are the leading cause of death worldwide. The Global Cancer Incidence, Mortality, and Prevalence (GLOBOCAN) 2020 estimated that there were 19,292,789 cancer cases and 9,958,133 cancer deaths in 2020 globally. Surgical tumor excision remains the primary approach for most cancers. Despite ...

Malignant cancers are the leading cause of death worldwide. The Global Cancer Incidence, Mortality, and Prevalence (GLOBOCAN) 2020 estimated that there were 19,292,789 cancer cases and 9,958,133 cancer deaths in 2020 globally. Surgical tumor excision remains the primary approach for most cancers. Despite improvements in surgical techniques over the years, combined treatments, such as surgery with chemotherapy, radiation therapy, and/or immunotherapy, have significantly prolonged the survival of patients with cancer. However, the high recurrence rate, metastasis rate, high incidence rate, and postoperative complications of cancer are still the main problems affecting the outcomes of cancer patients.

Perioperative management, including pre-, intra-, and post-operative care, and consisting of multidisciplinary approaches, is an important part of cancer treatment. Studies have suggested that anesthetic, analgesic, or other non-surgical perioperative interventions during cancer resection surgery might significantly influence cancer biology and outcomes. However, the exact impact of anesthesia or other perioperative factors on subsequent health status and quality of life in these cancer patients and the underlying mechanisms remain to be determined.

This Research Topic aims to provide an understanding and comprehensive discussion of how perioperative management impacts the outcome of patients after cancer resection surgery. By integrating the current knowledge regarding perioperative management and new improvements in optimal perioperative strategies, we hope that this Research Topic will collect the latest findings and perspectives on perioperative practices in cancer surgery patients and provide guidance for future clinical applications.

We welcome submissions of Original Research, Mini Review, and Review focusing on, but not limited to, the subtopics below:
• New strategies, technologies, or improvements in perioperative management for cancer resection surgery
• The impact of anesthesia (including anesthetics and/or anesthesia techniques) on cancer outcomes or subsequent health status in cancer patients
• The impact of analgesics or pain management strategies on cancer outcomes or subsequent health status in cancer patients
• The impact of perioperative emotional management (such as stress, depression, and anxiety) on cancer outcomes or subsequent health status in cancer patients
• Enhanced Recovery After Surgery (ERAS) implementation and outcomes of cancer patients
• The impact of other non-surgical perioperative interventions on cancer outcome or subsequent health status in cancer patients

Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.

Keywords: Anesthesia, analgesia, cancer, surgery, perioperative management


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