About this Research Topic
Specific trajectories could be described for psychiatric disorders. Those trajectories implied genetic factors referring to past family history of psychiatric disorders, environmental factors referring especially to stressful or traumatic events or exposition to toxic agent including drugs, and age of onset referring to neurodevelopmental stage of the individual.
Another way of saying this is that one individual could be vulnerable to an environment according to its genetic inheritance and that vulnerability could be different according to its brain maturity.
From a dynamic genetic perspective, this observation lead to consider the role of epigenetic mechanism in the interface between genetic factors, neurodevelopment and environment. Especially as neurodevelopmental some genetic disorders are associated with psychiatric symptoms which severity could be modulated by environmental factors.
The aim of the current Research Topic is to cover promising, recent, and novel research trends in the epigenetic and neurodevelopment field. Areas to be covered in this Research Topic may include, but are not limited to:
- epigenetic studies in neurodevelopmental disorders with psychiatric features
- hypothesis about epigenetic modulators (LncRNA, miRNA..) that could be involved in neurodevelopmental disorders with psychiatric features
- Therapeutic strategies involving epigenetic in neurodevelopmental disorders with psychiatric features
This topic aimed to document the epigenetic modulation in psychiatric disorders by considering neurodevelopmental trajectories.
As example we found that Prader Willi syndrome (PWS) is a neurodevelopmental disorder associated with psychiatric symptoms. In this syndrome gene responsive for the disorder has been identified among them a gene coding for LncRNA that could modulated epigenetic processes. We therefore postulated that the mutated genes of PWS could played a role in vulnerability to the environement and in the development of psychiatric symptoms of the syndrome.
Following this orientation, the proposals of this topic should concern epigenetic investigation in neurodevelopmental disorders with psychiatric features.
Another way of saying this is that one individual could be vulnerable to an environment according to its genetic inheritance and that vulnerability could be different according to its brain maturity.
From a dynamic genetic perspective, this observation lead to consider the role of epigenetic mechanism in the interface between genetic factors, neurodevelopment and environment. Especially as neurodevelopmental some genetic disorders are associated with psychiatric symptoms which severity could be modulated by environmental factors.
The aim of the current Research Topic is to cover promising, recent, and novel research trends in the epigenetic and neurodevelopment field. Areas to be covered in this Research Topic may include, but are not limited to:
- epigenetic studies in neurodevelopmental disorders with psychiatric features
- hypothesis about epigenetic modulators (LncRNA, miRNA..) that could be involved in neurodevelopmental disorders with psychiatric features
- Therapeutic strategies involving epigenetic in neurodevelopmental disorders with psychiatric features
This topic aimed to document the epigenetic modulation in psychiatric disorders by considering neurodevelopmental trajectories.
As example we found that Prader Willi syndrome (PWS) is a neurodevelopmental disorder associated with psychiatric symptoms. In this syndrome gene responsive for the disorder has been identified among them a gene coding for LncRNA that could modulated epigenetic processes. We therefore postulated that the mutated genes of PWS could played a role in vulnerability to the environement and in the development of psychiatric symptoms of the syndrome.
Following this orientation, the proposals of this topic should concern epigenetic investigation in neurodevelopmental disorders with psychiatric features.
Keywords: Neurodevelopment, epigenetics, psychiatric disorder
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