About this Research Topic
G protein-coupled receptors (GPCRs) are a superfamily of seven transmembrane receptors that recognize a diverse array of extracellular stimuli and widely exist in the central nervous system. These receptors modulate the key neurotransmitter systems and participate in many different cellular processes that could be disrupted in human diseases. Thus, GPCRs become potential therapeutic targets for a range of neurological and psychiatric disorders.
This research topic focuses on roles of GPCRs in modulating synaptic transmission, plasticity and higher brain functions in neurological (neurodevelopmental and neurodegenerative) and psychiatric diseases. The scope of this research topic includes, but is not limited to: deficits in GPCRs and their downstream signaling pathways in disease model organisms; molecular mechanisms underlying disruption of GPCR signalings in neurological and psychiatric disorders; modulation of neurotransmitter systems and synaptic plasticity by GPCRs in disease conditions; neural and behavioral responses to potential therapeutic strategies targeting GPCRs in disease model systems and the translational relevance of those targets to patients with neurological or psychiatric disorders.
Keywords: G protein-coupled receptors, synaptic plasticity, neuropsychiatric disorders, fragile X syndrome, autism, Alzheimer disease, metabotropic glutamate receptors, dopamine, serotonin, endocannabinoid
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