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The idea of one health, introduced at the beginning of the 2000s, is a worldwide strategy for creating an integrated and synergistic approach, aiming to balance and optimize the health of humans, animals and ecosystems. This is a latest international public health philosophy. The World Health Organization ...

The idea of one health, introduced at the beginning of the 2000s, is a worldwide strategy for creating an integrated and synergistic approach, aiming to balance and optimize the health of humans, animals and ecosystems. This is a latest international public health philosophy. The World Health Organization (WHO), the Food and Agriculture Organization of the United Nations (FAO) and the World Organization for Animal Health (OIE) have paid close attention to and supported this concept. While microbiome research has provided important guidance for understanding and managing the global health risks, and maintaining the ecological balance and sustainability.

The earlier research focused on microorganisms (bacteria, fungi, viruses and prions) as disease vectors, have led to tremendous advances in medicine. This understanding of microbiology has been accompanied by the development of methods for controlling infectious diseases. Previously when doctors and medical researchers worked on gut microbes, the microbes were often thought to be the organisms that benefit from maintaining a close bond with their host without generating any positive or harmful effects. More recently, however, it has been realized that the relationship between microbes and hosts might not be that simple and the research focused on the roles of microbes in their natural environment began to make its presence. This requires researchers to switch their focus of the investigation on microbial resources and human microbiome to a more comprehensive consideration regarding health, agriculture, ecological environment and other aspects, moreover, to pay more attention to interdisciplinary convergence.

This Research Topic aims to integrate the core concept of "One Health" with microbiology research from a holistic perspective of "human-animal-environmental" health. At the same time, we aim to create an exchange platform for the multi-institutional, interdisciplinary and cross-regional collaboration, to foster new ideas and opportunities, in the hope of opening the door to the unknown world through microbiological research.

The themes covered in this Research Topic are not limited to infectious diseases. We expect studies examining responses to microorganisms (bacteria, fungi, viruses, prions and gut microbes) focusing on Molecular interactions between microorganisms and hosts.

Potential topics include but are not limited to the following:
• Specific microbial characteristics related to the pathogenesis of diseases;
• Gastrointestinal health status (intestinal flora, genetic or environmental factors) and diseases;
• Regulatory mechanism of probiotics on immune function and gut microflora;
• Molecular regulation of tropical pathogenic microorganisms on host;
• Microbiology in the One Health: from mechanisms to therapeutic applications;
• Molecular mechanisms of inflammatory disease pathogenesis.

For this purpose, we are encouraging researchers to present their valuable work as the following article types: Original Research, Case Report, Review, Mini Review, Clinical Trial, Hypothesis and Theory, Methods, and Opinion. We will really appreciate your work and it will be a pleasure for us to receive your manuscripts.

Keywords: Intestinal microbiome, immune function, Pathogenic Microorganisms, pathogenesis of disease, One Health


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