High-grade gliomas have high malignancy, easy recurrence, and poor prognosis, present both in children and adults. The tumor survival microenvironment includes peripheral blood vessels, immune cells, fibroblasts, various signal molecules, and an extracellular matrix. The interaction between immune cells and glioma cells in the glioma microenvironment is the focus of current research, such as tumor-associated macrophages promoting glioma cell invasion, angiogenesis, and drug resistance; Glioma cells promote the reversal of polarization of tumor-associated macrophages from M1 type to M2 type.
There are many disputes about the relationship between the expression of immune cell phenotype in glioma microenvironment and patient age, tumor location, WHO grade, molecular pathological characteristics (Isocitrate dehydrogenase 1 mutation, Histone H3 lysine methionine replacement position 27 mutation), and the evaluation of recurrence mode; The mechanism of immune cell recruitment in glioma microenvironment is not clear; Whether peripheral immune cells can predict the molecular pathological status and prognosis of patients is unclear; The relationship between the expression of multiple immune checkpoints in immune cells and prognosis and drug resistance remains controversial.
The purpose of this study is to collect and study the relationship between immune cells in the microenvironment of high-grade glioma and patients' age, tumor location, WHO grade, molecular pathological characteristics, and prognosis, and evaluate them through imaging and spatial transcriptomics to guide treatment strategies. Neurooncology and neurosurgical oncology welcome the following types of articles: clinical trials, hypotheses and theories, small reviews, original studies, reviews, systematic reviews, editorials, methods, but do not include pure bioinformatics studies that have not been independently (non-database) clinically validated and/or in vitro or in vivo functional validated from patient-derived samples.
The scope of this study includes but is not limited to:
-Expression of peripheral blood immune cells in patients with high-grade gliomas and healthy people
-Predictive effect of peripheral blood immune cells on microenvironment immune status, tumor molecular pathological types, and recurrence patterns in patients with high-grade glioma
-Relationship between the expression of infiltrating immune cells in the microenvironment of high-grade gliomas and prognosis
-Relationship between immune cell expression and drug resistance in the advanced glioma microenvironment
High-grade gliomas have high malignancy, easy recurrence, and poor prognosis, present both in children and adults. The tumor survival microenvironment includes peripheral blood vessels, immune cells, fibroblasts, various signal molecules, and an extracellular matrix. The interaction between immune cells and glioma cells in the glioma microenvironment is the focus of current research, such as tumor-associated macrophages promoting glioma cell invasion, angiogenesis, and drug resistance; Glioma cells promote the reversal of polarization of tumor-associated macrophages from M1 type to M2 type.
There are many disputes about the relationship between the expression of immune cell phenotype in glioma microenvironment and patient age, tumor location, WHO grade, molecular pathological characteristics (Isocitrate dehydrogenase 1 mutation, Histone H3 lysine methionine replacement position 27 mutation), and the evaluation of recurrence mode; The mechanism of immune cell recruitment in glioma microenvironment is not clear; Whether peripheral immune cells can predict the molecular pathological status and prognosis of patients is unclear; The relationship between the expression of multiple immune checkpoints in immune cells and prognosis and drug resistance remains controversial.
The purpose of this study is to collect and study the relationship between immune cells in the microenvironment of high-grade glioma and patients' age, tumor location, WHO grade, molecular pathological characteristics, and prognosis, and evaluate them through imaging and spatial transcriptomics to guide treatment strategies. Neurooncology and neurosurgical oncology welcome the following types of articles: clinical trials, hypotheses and theories, small reviews, original studies, reviews, systematic reviews, editorials, methods, but do not include pure bioinformatics studies that have not been independently (non-database) clinically validated and/or in vitro or in vivo functional validated from patient-derived samples.
The scope of this study includes but is not limited to:
-Expression of peripheral blood immune cells in patients with high-grade gliomas and healthy people
-Predictive effect of peripheral blood immune cells on microenvironment immune status, tumor molecular pathological types, and recurrence patterns in patients with high-grade glioma
-Relationship between the expression of infiltrating immune cells in the microenvironment of high-grade gliomas and prognosis
-Relationship between immune cell expression and drug resistance in the advanced glioma microenvironment
