About this Research Topic
This Research Topic aims to review the history, discuss the current understanding and treatment modalities, and provide future directions for vascular malformations in the central nervous system. Recent genomic and transcriptomic advances at single-cell and bulk levels identify novel somatic mutations in sporadic vascular malformations and unravel new cell types and specific cross-talk between cell components. Additionally, the correlation between these new findings and classical disease models further convinces our knowledge of the development of vascular malformations. These molecular and cellular findings are promoting novel research models and therapeutic targets for vascular malformations to a new era. The treatment strategy and risk assessment system of both surgical and natural history will embrace an innovation of integrative molecular and radiomics classification for vascular malformations in the future. More collaborations between neurosurgeons (who obtain varied tissue samples for research and know the question of clinical importance), neurologists(who would be the future with therapeutic treatment), bioinformaticians (who can mine the high thorough-put data), radiologists(who find new imaging technique to define molecular and clinical features) and molecular biologist (who consolidate all the understandings of underlining mechanism), will contribute to more translational research to conquer the CNS vascular malformations.
The scope of this Research Topic is to explore the management and mechanism of CNS vascular malformation and relevant diseases for the improvement of patient care. We are interested in manuscripts that describe pathophysiology, etiology, epidemiology, diagnosis, surgical or medical therapies, and prognosis. Areas of interest for this Topic include but are not limited to:
-The biology of arteriovenous malformation, cavernous malformation, telangiectasia, and venous anomaly
-The natural history and epidemiology of CNS vascular malformations
-The diagnostic or prognostic biomarkers for CNS vascular malformations
-The imaging features and techniques for CNS vascular malformations
-The treatment modality and outcome for CNS vascular malformations
-The novel technique with an application to CNS vascular malformations
-The neuroplasticity and brain function in CNS vascular malformations
-The interplay or cross-talk among neuron-glia, vascular and immune cells in CNS vascular malformations
We welcome Original Research, Reviews, Systematic Reviews or Meta-analyses, and Case Reports.
Keywords: Central nervous system, Vascular malformation, Hemorrhage, Vascular development
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.