About this Research Topic
The most successful vaccines are effective because they induce neutralizing antibodies to immunodominant, stable epitopes. However, several medically and economically important viral pathogens present immunodominant, variable epitopes that induce humoral immune responses that are neither broad, nor long-lasting. To address this challenge, researchers are developing strategies that evoke a humoral immune response to non-immunodominant, conserved epitopes. Researchers are also developing “all-inclusive” strategies that include T cell-mediated immunity as well as B cell-mediated immunity. With these strategies in mind, it is hoped that broad, long-lasting immunity can be provided against prevailing viral pathogens, including influenza, SARS-CoV-2, and HIV. We want to attract researchers who are employing novel and emerging vaccination strategies, which address the current challenges in vaccinology.
The SARS-CoV-2 pandemic has fostered development of vaccines, drugs, and surveillance technologies at a rapid and unprecedented rate. This includes the development of novel vaccine technologies that will have far-reaching impact for many years to come. The goal of this Research Topic in Frontiers in Immunology is to bring together research on the many exciting and different strategies being developed for controlling viral pathogens. We want to create a Research Topic that consolidates recently gained information with well-grounded, historical data on vaccines and future vaccines. Non-immunodominant, variable epitopes of viruses remain a major hurdle towards vaccine development and we want to identify and interrogate factors that prevent the induction of broad and long-lasting immunity.
We welcome contributions from researchers who are working on virus biology, and on human and animal immunity in the context of virus control strategies. We would like to include Original Research, Review/Mini-Review and Perspective articles on a variety of medically and economically important viral pathogens.
Themes
1. Viral and host factors that prevent the induction of broad and long-lasting immunity
2. Novel and emerging vaccination strategies for inducing broad and long-lasting immunity
3. Characterization of broadly protective antibodies, and of long-lasting T cell-mediated immunity
The SARS-CoV-2 pandemic has fostered development of vaccines, drugs, and surveillance technologies at a rapid and unprecedented rate. This includes the development of novel vaccine technologies that will have far-reaching impact for many years to come. The goal of this Research Topic in Frontiers in Immunology is to bring together research on the many exciting and different strategies being developed for controlling viral pathogens. We want to create a Research Topic that consolidates recently gained information with well-grounded, historical data on vaccines and future vaccines. Non-immunodominant, variable epitopes of viruses remain a major hurdle towards vaccine development and we want to identify and interrogate factors that prevent the induction of broad and long-lasting immunity.
We welcome contributions from researchers who are working on virus biology, and on human and animal immunity in the context of virus control strategies. We would like to include Original Research, Review/Mini-Review and Perspective articles on a variety of medically and economically important viral pathogens.
Themes
1. Viral and host factors that prevent the induction of broad and long-lasting immunity
2. Novel and emerging vaccination strategies for inducing broad and long-lasting immunity
3. Characterization of broadly protective antibodies, and of long-lasting T cell-mediated immunity
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
