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The organelles such as mitochondria and endoplasmic reticulum are membrane systems that are relatively independent in structures and closely linked intracellularly. The coordination of these organelles efficiently supports the body's normal physiological activities and combats the destructive damages. On the ...

The organelles such as mitochondria and endoplasmic reticulum are membrane systems that are relatively independent in structures and closely linked intracellularly. The coordination of these organelles efficiently supports the body's normal physiological activities and combats the destructive damages. On the other hand, the imbalance of the cell membrane system leads to the imbalance of cell metabolism and the abnormal regulation of the intracellular signal network, resulting in uncontrollable, malignant regulation of cells and promoting malignant diseases.

This Research Topic wishes to provide a comprehensive understanding of subcellular organelles in metabolic homeostasis. The mitochondria and endoplasmic reticulum have unique distribution and contents of nucleic acids, proteins, and metabolites, which promote the efficient operation of various biochemical reactions and maintain their specific energy metabolism. Therefore, this Research Topic aims to analyze the components of the mitochondria and endoplasmic reticulum to reveal the unique functions and dynamic relationships of each organelle in crucial cell activities. Furthermore, we will explore the hierarchical spatial distribution of nucleic acids, proteins, and metabolites to explain how they dynamically regulate cell metabolism under physiological and pathological conditions.

We welcome the submission of papers in any area of metabolic biology and physiology of the mitochondria and endoplasmic reticulum, and interorganelle communication in cardiovascular physiology, immunology, signaling transduction, disease mechanisms, and therapeutics. The significant findings that raise the important biological and physiological questions related to other subcellular organelles are also welcome. Topics to be covered may include:
• Interorganelle communication, aging, and neurodegeneration.
• Metabolic signaling in immune cells.
• Mitochondria in the pathogenesis of human diseases and aging.
• Energetic interactions between the mitochondria and endoplasmic reticulum in specified tissues.
• Endoplasmic reticulum-mitochondria coupling in changing cellular conditions.
• The role of the mitochondria and endoplasmic reticulum in the regulation of stress response.

Keywords: metabolism, subcellular organelles, signaling, interorganelle communication, post-translational modification


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