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About this Research Topic

Manuscript Submission Deadline 12 April 2023

Experimental models can be utilized to better our understanding of the processes involved in human diseases, as well as to determine candidate drugs for their treatment, assess the effectiveness of these treatments and support their progression into clinical trials. Experimental models can be a useful way to inform our understanding of rare cardiac diseases, such as long QT syndrome (LQTS), brugada syndrome (BrS) and early repolarization syndrome (ERS).

This Research Topic welcomes basic, translational, clinical, and applied research that improves our understanding of mechanoelectrical coupling and arrhythmias. Potential areas of interest may include, but are not limited to:
- Gene Edited Animal Models
- Organoids and iPSC-CMs
- Small Animals
- Large Animals
- Optogenetics
- CRISPR-Cas9-based Animal Models

We welcome the submission of different article types to this collection, especially reviews, mini-reviews, and original research papers. For a complete list of article types that can be considered in the Integrative Physiology section, please follow this link. Even though abstract submission is not mandatory, we encourage all interested researchers to submit an abstract before submitting their manuscript. Abstracts do not have to coincide with the final abstract of the manuscripts.

This Research Topic is part of the Experimental Models and Model Organisms series of Frontiers in Physiology. Other titles in this series include:

Animal Models and Transgenic Technology in Craniofacial Biology
In Vitro Models: Opportunities and Challenges in Aquatic Physiology
Experimental Models and Model Organisms in Cardiac Electrophysiology: Opportunities and Challenges
Advances in Pluripotent Stem Cell-Based in Vitro Models of the Human Heart for Cardiac Physiology, Disease Modeling and Clinical Applications
Model Organisms: Opportunities and Challenges in Developmental Physiology
Model Organisms and Experimental Models: Opportunities and Challenges in Vascular Physiology Research
Invertebrates as Model Organisms: Opportunities and Challenges in Physiology and Bioscience Research
Model Organisms and Experimental Models: Opportunities and Challenges in Musculoskeletal Physiology
Model Organisms and Experimental Models: Opportunities and Challenges in Integrative Physiology
Model Organisms and Experimental Models: Opportunities and Challenges in Redox Physiology
Model Organisms and Experimental Models in Membrane Physiology and Membrane Biophysics: Opportunities and Challenges

Keywords: sudden cardiac death, CPVT, ventricular arrhythmogenesis, murine, mouse, action potential, monophasic action potential, calcium homeostasis, rare disease, cardiac disease, LQTS, BrS, ERS, Electrophysiology, Heart rhythm


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Experimental models can be utilized to better our understanding of the processes involved in human diseases, as well as to determine candidate drugs for their treatment, assess the effectiveness of these treatments and support their progression into clinical trials. Experimental models can be a useful way to inform our understanding of rare cardiac diseases, such as long QT syndrome (LQTS), brugada syndrome (BrS) and early repolarization syndrome (ERS).

This Research Topic welcomes basic, translational, clinical, and applied research that improves our understanding of mechanoelectrical coupling and arrhythmias. Potential areas of interest may include, but are not limited to:
- Gene Edited Animal Models
- Organoids and iPSC-CMs
- Small Animals
- Large Animals
- Optogenetics
- CRISPR-Cas9-based Animal Models

We welcome the submission of different article types to this collection, especially reviews, mini-reviews, and original research papers. For a complete list of article types that can be considered in the Integrative Physiology section, please follow this link. Even though abstract submission is not mandatory, we encourage all interested researchers to submit an abstract before submitting their manuscript. Abstracts do not have to coincide with the final abstract of the manuscripts.

This Research Topic is part of the Experimental Models and Model Organisms series of Frontiers in Physiology. Other titles in this series include:

Animal Models and Transgenic Technology in Craniofacial Biology
In Vitro Models: Opportunities and Challenges in Aquatic Physiology
Experimental Models and Model Organisms in Cardiac Electrophysiology: Opportunities and Challenges
Advances in Pluripotent Stem Cell-Based in Vitro Models of the Human Heart for Cardiac Physiology, Disease Modeling and Clinical Applications
Model Organisms: Opportunities and Challenges in Developmental Physiology
Model Organisms and Experimental Models: Opportunities and Challenges in Vascular Physiology Research
Invertebrates as Model Organisms: Opportunities and Challenges in Physiology and Bioscience Research
Model Organisms and Experimental Models: Opportunities and Challenges in Musculoskeletal Physiology
Model Organisms and Experimental Models: Opportunities and Challenges in Integrative Physiology
Model Organisms and Experimental Models: Opportunities and Challenges in Redox Physiology
Model Organisms and Experimental Models in Membrane Physiology and Membrane Biophysics: Opportunities and Challenges

Keywords: sudden cardiac death, CPVT, ventricular arrhythmogenesis, murine, mouse, action potential, monophasic action potential, calcium homeostasis, rare disease, cardiac disease, LQTS, BrS, ERS, Electrophysiology, Heart rhythm


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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