Immune Regulations of Inflammatory Skin Diseases

Skin is our primary interface with the environment, and T cells are crucial for orchestrating host immune responses against pathogenic microorganisms. Dysregulated immune responses, on the other hand, can result in chronic inflammatory skin diseases. The complex regulatory networks include effector T cells, memory T cells, regulatory T cells, immunoregulatory co-signaling molecules and cytokines that control skin immunity, and the mechanisms that regulate skin immune responses in host defense and in immune-mediated cutaneous diseases. The immune-regulatory networks are involved in the common inflammatory skin diseases, including psoriasis, atopic dermatitis, alopecia areata, vitiligo, bullous diseases, and cutaneous adverse drug reaction.

The goal of this Research Topic is to provide a forum to advance research on the contribution of skin inflammation to the genesis and development of the skin diseases as well as to explore innovative skin-oriented pharmacological interventions, mainly on the immune regulatory networks, in the attempt to achieve a beneficial impact on the skin disease course.

We welcome the submissions of Original Research and Review articles covering, but not limited to, the following subtopics:

1) Immune mechanisms of regulatory networks in immune-mediated cutaneous diseases

2) Immunopathology of T cell responses to immune-mediated cutaneous diseases

3) Therapeutic strategies on immune regulatory molecules and cytokines in immune-mediated cutaneous diseases

4) Human clinical trials using immune regulatory molecules and cytokines in immune-mediated cutaneous diseases

5) Immune checkpoint inhibitors induced cutaneous immune-mediated adverse events

6) Methods of targeting regulatory T cells, memory T cells, and effector T cells in immune-mediated cutaneous diseases

7) Personalized immunotherapies of immune-mediated cutaneous diseases