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About this Research Topic

Manuscript Submission Deadline 14 September 2022
Manuscript Extension Submission Deadline 14 October 2022

Cardiovascular diseases (CVD) are the leading causes of death globally. According to statistics reported by American Heart Association (AHA) in 2022, the prevalence of CVD among adults (>20 years old) is around 50% in the United States. The CVD are often associated with very high mortality accounting for 1/3 deaths in US annually. Financial burden caused by CVD is roughly 1 billion per day in the United States. The pathology of these diseases is highly complex. Recently, there has been an increasing awareness and consensus that mechanical stresses especially those from blood flow or hemodynamics are one of the key factors that regulate the pathological processes of CVD at molecular, cellular and tissue levels.

The primary goal of this Research Topic is to solicit the recent works on how biofluid and biomechanical stresses affect the onset and pathways of the cardio-vascular diseases (CVDs). The research field of CVD is highly interdisciplinary which requires interdisciplinary approaches. As a result, research that integrates in vitro and in vivo experimental techniques, advanced computational techniques and hypothesis-driven thinking will be highlighted. The overarching goal of this collection is to facilitate cross-talk between the engineering and medicine world, where engineers, physicist, chemists, biologists and clinicians can enjoy a platform to share their perspectives as a whole.

This Research Topic will cover the most recent progresses in various biomechanical and mechanobiological aspects of hematologic and cardiovascular diseases. Topics of particular interests include following:
1) Multiscale and/or data-driven modelling of cardiovascular and hematologic diseases
2) Biotransport and adhesion of cells and biomolecules in blood flows
3) Targeted drug delivery for cardio-vascular diseases
4) Lab-on-a-chip for thrombosis and bleeding characterization
5) Hemodynamics and clot formation in patient geometries and blood-contacting devices
6) Complex fluid-structure interaction in cardiac flows
7) Advanced in vivo and in vitro imaging techniques for blood flow
8) COVID-19 related blood clotting and disorders

Keywords: Biofluids, Biomechanics, Mechanobiology, Hematologic disorders, Cardiac flows, Blood flows, Heart valve, Blood clotting, Bleeding, Thrombosis and Hemostasis


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Cardiovascular diseases (CVD) are the leading causes of death globally. According to statistics reported by American Heart Association (AHA) in 2022, the prevalence of CVD among adults (>20 years old) is around 50% in the United States. The CVD are often associated with very high mortality accounting for 1/3 deaths in US annually. Financial burden caused by CVD is roughly 1 billion per day in the United States. The pathology of these diseases is highly complex. Recently, there has been an increasing awareness and consensus that mechanical stresses especially those from blood flow or hemodynamics are one of the key factors that regulate the pathological processes of CVD at molecular, cellular and tissue levels.

The primary goal of this Research Topic is to solicit the recent works on how biofluid and biomechanical stresses affect the onset and pathways of the cardio-vascular diseases (CVDs). The research field of CVD is highly interdisciplinary which requires interdisciplinary approaches. As a result, research that integrates in vitro and in vivo experimental techniques, advanced computational techniques and hypothesis-driven thinking will be highlighted. The overarching goal of this collection is to facilitate cross-talk between the engineering and medicine world, where engineers, physicist, chemists, biologists and clinicians can enjoy a platform to share their perspectives as a whole.

This Research Topic will cover the most recent progresses in various biomechanical and mechanobiological aspects of hematologic and cardiovascular diseases. Topics of particular interests include following:
1) Multiscale and/or data-driven modelling of cardiovascular and hematologic diseases
2) Biotransport and adhesion of cells and biomolecules in blood flows
3) Targeted drug delivery for cardio-vascular diseases
4) Lab-on-a-chip for thrombosis and bleeding characterization
5) Hemodynamics and clot formation in patient geometries and blood-contacting devices
6) Complex fluid-structure interaction in cardiac flows
7) Advanced in vivo and in vitro imaging techniques for blood flow
8) COVID-19 related blood clotting and disorders

Keywords: Biofluids, Biomechanics, Mechanobiology, Hematologic disorders, Cardiac flows, Blood flows, Heart valve, Blood clotting, Bleeding, Thrombosis and Hemostasis


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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