About this Research Topic
Oligodendrocytes are key non-neuronal cells that are generated from oligodendrocyte progenitor cells (OPCs). OPCs migrate thought out the CNS and mature into oligodendrocytes via a well-controlled and orchestrated process. Mature oligodendrocytes are responsible for myelin formation and maintenance in the central nervous system (CNS) enhancing neuronal function. Myelination of neuronal axons by oligodendrocytes is a well-regulated and dynamic process determined by complex cellular interactions. Additionally, it has been recently described that oligodendrocytes play an important role in providing axonal trophic support.
Although oligodendrocytes dysfunction is not necessarily a sign of disease, it is part of the physiological process of aging, axon demyelination has been implicated in many diseases of the CNS such as neuropsychiatric and neurodegenerative diseases.
Unraveling the mechanisms behind oligodendrocytes’ formation and function may lead to a better understanding of their dysfunction and their role in CNS pathologies.
In this Research Topic, Frontiers in Cellular Neuroscience is looking to address key aspects of “Oligodendrocytes: From Their Development to Function and Dysfunction” in order to promote the discussion around this topic and to facilitate knowledge dissemination.
We particularly welcome submission of Original Research, Review, Methods, and Perspective articles including, but not limited to, the following sub-topics:
• Developmental mechanisms of oligodendrocyte progenitor cells
• Molecular mechanisms of oligodendrocyte progenitor cells migrations and differentiation
• Functional roles of oligodendrocyte progenitor cells and mature oligodendrocytes after white matter injury
• Molecular mechanisms of myelin formation
• Molecular mechanisms of remyelination
• Molecular mechanisms of interactions between myelin sheath and axons
• Molecular mechanisms of oligodendrocyte functions in the onset of neurodegenerative diseases and psychiatric disorders
Although oligodendrocytes dysfunction is not necessarily a sign of disease, it is part of the physiological process of aging, axon demyelination has been implicated in many diseases of the CNS such as neuropsychiatric and neurodegenerative diseases.
Unraveling the mechanisms behind oligodendrocytes’ formation and function may lead to a better understanding of their dysfunction and their role in CNS pathologies.
In this Research Topic, Frontiers in Cellular Neuroscience is looking to address key aspects of “Oligodendrocytes: From Their Development to Function and Dysfunction” in order to promote the discussion around this topic and to facilitate knowledge dissemination.
We particularly welcome submission of Original Research, Review, Methods, and Perspective articles including, but not limited to, the following sub-topics:
• Developmental mechanisms of oligodendrocyte progenitor cells
• Molecular mechanisms of oligodendrocyte progenitor cells migrations and differentiation
• Functional roles of oligodendrocyte progenitor cells and mature oligodendrocytes after white matter injury
• Molecular mechanisms of myelin formation
• Molecular mechanisms of remyelination
• Molecular mechanisms of interactions between myelin sheath and axons
• Molecular mechanisms of oligodendrocyte functions in the onset of neurodegenerative diseases and psychiatric disorders
Keywords: Oligodendrocytes, brain disease, neurodegeneration, oligodendrocyte progenitor cells, myelin, remyelination
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
