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About this Research Topic

Manuscript Submission Deadline 20 September 2022
Manuscript Extension Submission Deadline 20 October 2022

Modulation of ion channels has been a successful area for drug development in the treatment of cardiovascular diseases such as arrhythmias, angina, hypertension, and diabetes. However, most of the commercialized ion channel modulators were developed without extensive knowledge of their molecular structure and ...

Modulation of ion channels has been a successful area for drug development in the treatment of cardiovascular diseases such as arrhythmias, angina, hypertension, and diabetes. However, most of the commercialized ion channel modulators were developed without extensive knowledge of their molecular structure and intricate regulation. Ion channels expressed in organellar membranes of cardiomyocytes, fibroblasts, pericytes, smooth muscle, endothelial and inflammatory cells play a key role in the functionality and homeostasis of the heart and vasculature. In recent years, new channelopathies and genetic variants affecting cardiovascular physiology have been identified. Our knowledge of how different extracellular and intracellular conditions (oxygen levels, calcium, pH, temperature, cell volume, hormones, stress, mechanical damage, drugs, toxins, and viral proteins) modulate the ion channels compromising their activity during pathophysiological processes has grown exponentially. New ligands, new transporter complexes, new gene and post-transcriptional regulations on ion channel-encoding genes mediated by transcription factors, lncRNA, and microRNAs have been discovered. All this innovative information contributes to the design of promising therapeutic tools that directly or indirectly regulate ion channel functions in the field of cardiovascular diseases.

The scope of this Research Topic is to compile a collection of articles that help comprehensively to identify, promote and develop new therapeutic tools and methods to ameliorate, alleviate and address ion channel dysfunction in the context of cardiovascular disease. Alternatively, contributors are encouraged to discuss existing and/or potential interventions for modulating ion channels in the context of disease status. The overall goal is to enhance better understanding of the mechanistic regulation and the significance of the ion channel functional modifications to feature more selective and accurate therapeutic targets.

Within this Research Topic we welcome submissions of Original Research, Brief Research Reports, Reviews or Mini Reviews, Systematic Reviews, and Methods to address research exploring:

• Identification and characterization of new molecular mechanisms/players in the cardio-vascular system that modulate gene/protein levels, intracellular localization, trafficking and functions of ion channels.
• The physiological impact of new gene variants related to cardiovascular channelopathies.
• Study of novel roles of ion channels in intracellular organelles such as mitochondria, sarcoplasmic reticulum, and nucleus.
• Gene therapies and novel pharmacological ion channel modulators for the treatment of cardiovascular diseases.
• Translational and clinical research in novel ion channel-targeted treatments for cardio-vascular diseases.
• Study of electrical/mechanical/structural alterations related to ion channel dysfunction and clinical outcomes.
• New methods to modelling ion channel dysfunction in cardiovascular diseases.

Keywords: Ion Channels, Cardiovascular Diseases, Channelopathies, Human variants, Drug discovery, Pharmacology, Cardiovascular Electrophysiology, Therapeutic Target


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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