Though cancer and other proliferative diseases are mainly caused by uncontrolled cell proliferation, neurodegenerative disorders (NDs) are marked by neuronal loss and gradual deterioration of various parts of the nervous system. Cancer and neurodegenerative disorders (NDs) share multiple genes and biological pathways that are closely engaged in mitochondrial dysfunction, oxidative stress, inflammatory responses, metabolic deregulation, DNA damage, and abnormal cell cycle activation, despite working in opposite directions (uncontrolled cell proliferation and cellular degeneration). Although neurodegenerative illnesses and cancer are generally treated separately, they have a complex and intriguing interrelationship. Aging is a crucial determinant in the connection between the two conditions. Several cancer-specific therapeutics, such as kinase inhibitors, developed for a variety of oncology indications, have shown significant neuroprotective effects in patients with NDs. The heterogeneity of the disease and the lack of significant therapeutic advances both in cancer and NDs justify the necessity for innovative and substantial drug discovery strategies. It is essential to update the understanding of the molecular mechanism of the disease manifestation to combat these devastating diseases more precisely and safely.
This Research Topic will emphasize molecular and genetic mechanisms and pharmacological therapeutic targets, with the intent of developing effective therapeutics that can be used to alleviate debilitating conditions and contribute to extending the lifespan of those who are afflicted.
We pursue Original Research, Review, Mini-Review, Hypothesis and Theory, Perspective, Clinical Trial, Case Report and Opinion articles that cover broadly the mechanism and therapeutic interventions of both cancer and NDs.
Though cancer and other proliferative diseases are mainly caused by uncontrolled cell proliferation, neurodegenerative disorders (NDs) are marked by neuronal loss and gradual deterioration of various parts of the nervous system. Cancer and neurodegenerative disorders (NDs) share multiple genes and biological pathways that are closely engaged in mitochondrial dysfunction, oxidative stress, inflammatory responses, metabolic deregulation, DNA damage, and abnormal cell cycle activation, despite working in opposite directions (uncontrolled cell proliferation and cellular degeneration). Although neurodegenerative illnesses and cancer are generally treated separately, they have a complex and intriguing interrelationship. Aging is a crucial determinant in the connection between the two conditions. Several cancer-specific therapeutics, such as kinase inhibitors, developed for a variety of oncology indications, have shown significant neuroprotective effects in patients with NDs. The heterogeneity of the disease and the lack of significant therapeutic advances both in cancer and NDs justify the necessity for innovative and substantial drug discovery strategies. It is essential to update the understanding of the molecular mechanism of the disease manifestation to combat these devastating diseases more precisely and safely.
This Research Topic will emphasize molecular and genetic mechanisms and pharmacological therapeutic targets, with the intent of developing effective therapeutics that can be used to alleviate debilitating conditions and contribute to extending the lifespan of those who are afflicted.
We pursue Original Research, Review, Mini-Review, Hypothesis and Theory, Perspective, Clinical Trial, Case Report and Opinion articles that cover broadly the mechanism and therapeutic interventions of both cancer and NDs.
