Skip to main content

About this Research Topic

Submission closed.

The calcium sensing receptor (CaSR) is a class C G protein-coupled receptor that plays a pivotal role in systemic calcium metabolism by regulating parathyroid hormone secretion and urinary calcium excretion. Abnormal CaSR function is implicated in calciotropic disorders such as hyperparathyroidism, and in ...

The calcium sensing receptor (CaSR) is a class C G protein-coupled receptor that plays a pivotal role in systemic calcium metabolism by regulating parathyroid hormone secretion and urinary calcium excretion. Abnormal CaSR function is implicated in calciotropic disorders such as hyperparathyroidism, and in non-calciotropic disorders including cancer, cardiovascular disease, respiratory disease, sarcopenia and Alzheimer’s disease, which account for >25% of the global disease burden. CaSR is a unique GPCR whose principal physiological agonist is the calcium ion. CaSR is expressed almost ubiquitously. CaSR interacts with multiple heterotrimeric G protein subtypes thereby regulating highly divergent downstream signaling pathways, depending upon cellular context. Near ubiquitous expression and lack of CaSR isoforms presents challenges in development of disease-specific treatments without concomitant on-target side effects. Current approaches include development of biased agonists and/or targeting disease-specific epigenetic changes or regulation of subcellular localization. A broad understanding of the genetic, molecular, and cellular regulation of CaSR expression and signaling is crucial to understanding both its importance in normal physiology and devising unique, targeted treatments to treat disease.

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Topic Editors

Loading..

Topic Coordinators

Loading..

Recent Articles

Loading..

Articles

Sort by:

Loading..

Authors

Loading..

views

total views views downloads topic views

}
 
Top countries
Top referring sites
Loading..

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.